Cargando…
The Risk Factors for Progression to Chronic Pancreatitis in Patients with Past-History of Acute Pancreatitis: A Retrospective Analysis Based on Mechanistic Definition
Background: According to the mechanistic definition, the history of acute pancreatitis (AP) is a risk factor for chronic pancreatitis (CP). However, the etiology and severity of previous AP involved in the progression to CP have not been clarified. Here, we investigated risk factors for the progress...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9032682/ https://www.ncbi.nlm.nih.gov/pubmed/35456301 http://dx.doi.org/10.3390/jcm11082209 |
_version_ | 1784692704737755136 |
---|---|
author | Yamamiya, Akira Tominaga, Keiichi Hoshi, Koki Nagashima, Kazunori Minaguchi, Takahito Haruyama, Yasuo Irisawa, Atsushi |
author_facet | Yamamiya, Akira Tominaga, Keiichi Hoshi, Koki Nagashima, Kazunori Minaguchi, Takahito Haruyama, Yasuo Irisawa, Atsushi |
author_sort | Yamamiya, Akira |
collection | PubMed |
description | Background: According to the mechanistic definition, the history of acute pancreatitis (AP) is a risk factor for chronic pancreatitis (CP). However, the etiology and severity of previous AP involved in the progression to CP have not been clarified. Here, we investigated risk factors for the progression to CP in patients with past-history of AP. Methods: Sixty-four patients with AP who were followed-up for at least two years at our institution between April 2009 and March 2017 were enrolled. The multivariate analysis was performed based on the risk factors extracted by univariate analysis. Results: Among the 64 patients, 13 patients (20.3%) progressed to CP (PCP group), while 48 did not (non-PCP group). Regarding the etiology of AP, rate of alcohol AP was significantly higher in the PCP group (76.9% vs. 33.3%, p = 0.003). In univariate analysis, smoking, number of previous AP, and alcohol consumption and drinking habits (Alcohol Use Disorders Identification Test-Concise; AUDIT-C) were identified as factors associated with progression to CP. Furthermore, multivariate analysis showed that AUDIT-C ≥ 6 points (male) and 4 points (female) after AP was a significant risk factor for CP (p = 0.003). Conclusions: Our results indicated that AUDIT-C ≥ 6 points (male) and 4 points (female) after AP was a risk factor in the process of progression to CP in patients with past-history of AP. |
format | Online Article Text |
id | pubmed-9032682 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-90326822022-04-23 The Risk Factors for Progression to Chronic Pancreatitis in Patients with Past-History of Acute Pancreatitis: A Retrospective Analysis Based on Mechanistic Definition Yamamiya, Akira Tominaga, Keiichi Hoshi, Koki Nagashima, Kazunori Minaguchi, Takahito Haruyama, Yasuo Irisawa, Atsushi J Clin Med Article Background: According to the mechanistic definition, the history of acute pancreatitis (AP) is a risk factor for chronic pancreatitis (CP). However, the etiology and severity of previous AP involved in the progression to CP have not been clarified. Here, we investigated risk factors for the progression to CP in patients with past-history of AP. Methods: Sixty-four patients with AP who were followed-up for at least two years at our institution between April 2009 and March 2017 were enrolled. The multivariate analysis was performed based on the risk factors extracted by univariate analysis. Results: Among the 64 patients, 13 patients (20.3%) progressed to CP (PCP group), while 48 did not (non-PCP group). Regarding the etiology of AP, rate of alcohol AP was significantly higher in the PCP group (76.9% vs. 33.3%, p = 0.003). In univariate analysis, smoking, number of previous AP, and alcohol consumption and drinking habits (Alcohol Use Disorders Identification Test-Concise; AUDIT-C) were identified as factors associated with progression to CP. Furthermore, multivariate analysis showed that AUDIT-C ≥ 6 points (male) and 4 points (female) after AP was a significant risk factor for CP (p = 0.003). Conclusions: Our results indicated that AUDIT-C ≥ 6 points (male) and 4 points (female) after AP was a risk factor in the process of progression to CP in patients with past-history of AP. MDPI 2022-04-15 /pmc/articles/PMC9032682/ /pubmed/35456301 http://dx.doi.org/10.3390/jcm11082209 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Yamamiya, Akira Tominaga, Keiichi Hoshi, Koki Nagashima, Kazunori Minaguchi, Takahito Haruyama, Yasuo Irisawa, Atsushi The Risk Factors for Progression to Chronic Pancreatitis in Patients with Past-History of Acute Pancreatitis: A Retrospective Analysis Based on Mechanistic Definition |
title | The Risk Factors for Progression to Chronic Pancreatitis in Patients with Past-History of Acute Pancreatitis: A Retrospective Analysis Based on Mechanistic Definition |
title_full | The Risk Factors for Progression to Chronic Pancreatitis in Patients with Past-History of Acute Pancreatitis: A Retrospective Analysis Based on Mechanistic Definition |
title_fullStr | The Risk Factors for Progression to Chronic Pancreatitis in Patients with Past-History of Acute Pancreatitis: A Retrospective Analysis Based on Mechanistic Definition |
title_full_unstemmed | The Risk Factors for Progression to Chronic Pancreatitis in Patients with Past-History of Acute Pancreatitis: A Retrospective Analysis Based on Mechanistic Definition |
title_short | The Risk Factors for Progression to Chronic Pancreatitis in Patients with Past-History of Acute Pancreatitis: A Retrospective Analysis Based on Mechanistic Definition |
title_sort | risk factors for progression to chronic pancreatitis in patients with past-history of acute pancreatitis: a retrospective analysis based on mechanistic definition |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9032682/ https://www.ncbi.nlm.nih.gov/pubmed/35456301 http://dx.doi.org/10.3390/jcm11082209 |
work_keys_str_mv | AT yamamiyaakira theriskfactorsforprogressiontochronicpancreatitisinpatientswithpasthistoryofacutepancreatitisaretrospectiveanalysisbasedonmechanisticdefinition AT tominagakeiichi theriskfactorsforprogressiontochronicpancreatitisinpatientswithpasthistoryofacutepancreatitisaretrospectiveanalysisbasedonmechanisticdefinition AT hoshikoki theriskfactorsforprogressiontochronicpancreatitisinpatientswithpasthistoryofacutepancreatitisaretrospectiveanalysisbasedonmechanisticdefinition AT nagashimakazunori theriskfactorsforprogressiontochronicpancreatitisinpatientswithpasthistoryofacutepancreatitisaretrospectiveanalysisbasedonmechanisticdefinition AT minaguchitakahito theriskfactorsforprogressiontochronicpancreatitisinpatientswithpasthistoryofacutepancreatitisaretrospectiveanalysisbasedonmechanisticdefinition AT haruyamayasuo theriskfactorsforprogressiontochronicpancreatitisinpatientswithpasthistoryofacutepancreatitisaretrospectiveanalysisbasedonmechanisticdefinition AT irisawaatsushi theriskfactorsforprogressiontochronicpancreatitisinpatientswithpasthistoryofacutepancreatitisaretrospectiveanalysisbasedonmechanisticdefinition AT yamamiyaakira riskfactorsforprogressiontochronicpancreatitisinpatientswithpasthistoryofacutepancreatitisaretrospectiveanalysisbasedonmechanisticdefinition AT tominagakeiichi riskfactorsforprogressiontochronicpancreatitisinpatientswithpasthistoryofacutepancreatitisaretrospectiveanalysisbasedonmechanisticdefinition AT hoshikoki riskfactorsforprogressiontochronicpancreatitisinpatientswithpasthistoryofacutepancreatitisaretrospectiveanalysisbasedonmechanisticdefinition AT nagashimakazunori riskfactorsforprogressiontochronicpancreatitisinpatientswithpasthistoryofacutepancreatitisaretrospectiveanalysisbasedonmechanisticdefinition AT minaguchitakahito riskfactorsforprogressiontochronicpancreatitisinpatientswithpasthistoryofacutepancreatitisaretrospectiveanalysisbasedonmechanisticdefinition AT haruyamayasuo riskfactorsforprogressiontochronicpancreatitisinpatientswithpasthistoryofacutepancreatitisaretrospectiveanalysisbasedonmechanisticdefinition AT irisawaatsushi riskfactorsforprogressiontochronicpancreatitisinpatientswithpasthistoryofacutepancreatitisaretrospectiveanalysisbasedonmechanisticdefinition |