Biological Evaluation of New Thienopyridinium and Thienopyrimidinium Derivatives as Human Choline Kinase Inhibitors

Due to its role in lipid biosynthesis, choline kinase α1 (CKα1) is an interesting target for the development of new antitumor agents. In this work, we present a series of 41 compounds designed based on the well-known and successful strategy of introducing thienopyridine and pyrimidine as bioisostere...

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Detalles Bibliográficos
Autores principales: Luque-Navarro, Pilar María, Mariotto, Elena, Ballarotto, Marco, Rubbini, Gianluca, Aguilar-Troyano, Francisco José, Fasiolo, Alberto, Torretta, Archimede, Parisini, Emilio, Macchiarulo, Antonio, Laso, Alejandro, Marco, Carmen, Viola, Giampietro, Carrasco-Jimenez, María Paz, López-Cara, Luisa Carlota
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9032693/
https://www.ncbi.nlm.nih.gov/pubmed/35456549
http://dx.doi.org/10.3390/pharmaceutics14040715

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