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The Curcumin Supplementation with Piperine Can Influence the Acute Elevation of Exercise-Induced Cytokines: Double-Blind Crossover Study

SIMPLE SUMMARY: Inflammation is an immune response to harmful stimuli, such as pathogens and damaged cells. Intense exercise can induce a local and systemic inflammatory response as well. We believe that exercise-induced inflammatory responses are essential for muscle repair and regeneration. Howeve...

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Autores principales: Miranda-Castro, Stéfani, Aidar, Felipe J., de Moura, Samara Silva, Marcucci-Barbosa, Lucas, Lobo, Lázaro Fernandes, de Assis Dias Martins-Júnior, Francisco, da Silva Filha, Roberta, Vaz de Castro, Pedro Alves Soares, Simões e Silva, Ana Cristina, da Glória de Souza, Danielle, da Silva, Siomara Aparecida, de Castro Pinto, Kelerson Mauro, de Paula Costa, Guilherme, Silva, Ana Filipa, Clemente, Filipe Manuel, Pereira, William Valadares Campos, Nunes-Silva, Albená
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9032800/
https://www.ncbi.nlm.nih.gov/pubmed/35453772
http://dx.doi.org/10.3390/biology11040573
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author Miranda-Castro, Stéfani
Aidar, Felipe J.
de Moura, Samara Silva
Marcucci-Barbosa, Lucas
Lobo, Lázaro Fernandes
de Assis Dias Martins-Júnior, Francisco
da Silva Filha, Roberta
Vaz de Castro, Pedro Alves Soares
Simões e Silva, Ana Cristina
da Glória de Souza, Danielle
da Silva, Siomara Aparecida
de Castro Pinto, Kelerson Mauro
de Paula Costa, Guilherme
Silva, Ana Filipa
Clemente, Filipe Manuel
Pereira, William Valadares Campos
Nunes-Silva, Albená
author_facet Miranda-Castro, Stéfani
Aidar, Felipe J.
de Moura, Samara Silva
Marcucci-Barbosa, Lucas
Lobo, Lázaro Fernandes
de Assis Dias Martins-Júnior, Francisco
da Silva Filha, Roberta
Vaz de Castro, Pedro Alves Soares
Simões e Silva, Ana Cristina
da Glória de Souza, Danielle
da Silva, Siomara Aparecida
de Castro Pinto, Kelerson Mauro
de Paula Costa, Guilherme
Silva, Ana Filipa
Clemente, Filipe Manuel
Pereira, William Valadares Campos
Nunes-Silva, Albená
author_sort Miranda-Castro, Stéfani
collection PubMed
description SIMPLE SUMMARY: Inflammation is an immune response to harmful stimuli, such as pathogens and damaged cells. Intense exercise can induce a local and systemic inflammatory response as well. We believe that exercise-induced inflammatory responses are essential for muscle repair and regeneration. However, uncontrolled acute inflammation in athletes during the training process and competition could reduce the level of performance. In this study, we investigate the effects of curcumin and piperine on the exercise-induced inflammatory response. ABSTRACT: Background: to evaluate the effects of one week of supplementation with curcumin combined with piperine on physical performance, immune system cell counts, muscle damage, and plasma levels of inflammatory markers after a treadmill running training session. Methods: This study is a double-blind, crossover-balanced clinical trial with a three-week intervention. Sixteen male runners with a mean age of 36 ± 9 years and VO2 max of 60.6 ± 9.03 mL.kg (−1) min (−1) were recruited and randomly divided into 2 groups: the first group (CPG) was supplemented daily for 7 days with 500 mg of curcumin + 20 mg piperine, and the second group (PG) was supplemented with 540 mg of cellulose. After the 7th day of supplementation, the volunteers participated in the experimental running protocol, where blood samples were collected before, after, and one hour after exercise for analysis of the number of leukocytes, creatine kinase, and cytokine concentration (IL-2, TNF-α, IFN, IL-6, and IL-10) using flow cytometry. This process was repeated, reversing the supplementation offered to the groups. Results: curcumin and piperine supplementation could not change the physical performance, immune cell counts, and muscle damage; however, the aerobic fatiguing exercise protocol inhibited the elevation of the plasmatic levels of some cytokines. The running exercise protocol could elevate the circulating levels of IL-2 (from 49.7 to 59.3 pg/mL), TNF-α (from 48.5 to 51.5 pg/mL), INF (from 128.8 to 165.0 pg/mL), IL-6 (from 63.1 to 77.3 pg/mL), and IL-10 (from 48.9 to 59.6 pg/mL) 1 h after the end of the running protocol. However, the curcumin and piperine supplementation could inhibit this elevation. Conclusions: curcumin and piperine supplementation had no effect on physical performance, immune cell counts, or muscle damage; however, the supplementation could modulate the kinetics of IL-2, TNF-α, INF, IL-6, and IL-10 1 h after the end of exercise.
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spelling pubmed-90328002022-04-23 The Curcumin Supplementation with Piperine Can Influence the Acute Elevation of Exercise-Induced Cytokines: Double-Blind Crossover Study Miranda-Castro, Stéfani Aidar, Felipe J. de Moura, Samara Silva Marcucci-Barbosa, Lucas Lobo, Lázaro Fernandes de Assis Dias Martins-Júnior, Francisco da Silva Filha, Roberta Vaz de Castro, Pedro Alves Soares Simões e Silva, Ana Cristina da Glória de Souza, Danielle da Silva, Siomara Aparecida de Castro Pinto, Kelerson Mauro de Paula Costa, Guilherme Silva, Ana Filipa Clemente, Filipe Manuel Pereira, William Valadares Campos Nunes-Silva, Albená Biology (Basel) Article SIMPLE SUMMARY: Inflammation is an immune response to harmful stimuli, such as pathogens and damaged cells. Intense exercise can induce a local and systemic inflammatory response as well. We believe that exercise-induced inflammatory responses are essential for muscle repair and regeneration. However, uncontrolled acute inflammation in athletes during the training process and competition could reduce the level of performance. In this study, we investigate the effects of curcumin and piperine on the exercise-induced inflammatory response. ABSTRACT: Background: to evaluate the effects of one week of supplementation with curcumin combined with piperine on physical performance, immune system cell counts, muscle damage, and plasma levels of inflammatory markers after a treadmill running training session. Methods: This study is a double-blind, crossover-balanced clinical trial with a three-week intervention. Sixteen male runners with a mean age of 36 ± 9 years and VO2 max of 60.6 ± 9.03 mL.kg (−1) min (−1) were recruited and randomly divided into 2 groups: the first group (CPG) was supplemented daily for 7 days with 500 mg of curcumin + 20 mg piperine, and the second group (PG) was supplemented with 540 mg of cellulose. After the 7th day of supplementation, the volunteers participated in the experimental running protocol, where blood samples were collected before, after, and one hour after exercise for analysis of the number of leukocytes, creatine kinase, and cytokine concentration (IL-2, TNF-α, IFN, IL-6, and IL-10) using flow cytometry. This process was repeated, reversing the supplementation offered to the groups. Results: curcumin and piperine supplementation could not change the physical performance, immune cell counts, and muscle damage; however, the aerobic fatiguing exercise protocol inhibited the elevation of the plasmatic levels of some cytokines. The running exercise protocol could elevate the circulating levels of IL-2 (from 49.7 to 59.3 pg/mL), TNF-α (from 48.5 to 51.5 pg/mL), INF (from 128.8 to 165.0 pg/mL), IL-6 (from 63.1 to 77.3 pg/mL), and IL-10 (from 48.9 to 59.6 pg/mL) 1 h after the end of the running protocol. However, the curcumin and piperine supplementation could inhibit this elevation. Conclusions: curcumin and piperine supplementation had no effect on physical performance, immune cell counts, or muscle damage; however, the supplementation could modulate the kinetics of IL-2, TNF-α, INF, IL-6, and IL-10 1 h after the end of exercise. MDPI 2022-04-10 /pmc/articles/PMC9032800/ /pubmed/35453772 http://dx.doi.org/10.3390/biology11040573 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Miranda-Castro, Stéfani
Aidar, Felipe J.
de Moura, Samara Silva
Marcucci-Barbosa, Lucas
Lobo, Lázaro Fernandes
de Assis Dias Martins-Júnior, Francisco
da Silva Filha, Roberta
Vaz de Castro, Pedro Alves Soares
Simões e Silva, Ana Cristina
da Glória de Souza, Danielle
da Silva, Siomara Aparecida
de Castro Pinto, Kelerson Mauro
de Paula Costa, Guilherme
Silva, Ana Filipa
Clemente, Filipe Manuel
Pereira, William Valadares Campos
Nunes-Silva, Albená
The Curcumin Supplementation with Piperine Can Influence the Acute Elevation of Exercise-Induced Cytokines: Double-Blind Crossover Study
title The Curcumin Supplementation with Piperine Can Influence the Acute Elevation of Exercise-Induced Cytokines: Double-Blind Crossover Study
title_full The Curcumin Supplementation with Piperine Can Influence the Acute Elevation of Exercise-Induced Cytokines: Double-Blind Crossover Study
title_fullStr The Curcumin Supplementation with Piperine Can Influence the Acute Elevation of Exercise-Induced Cytokines: Double-Blind Crossover Study
title_full_unstemmed The Curcumin Supplementation with Piperine Can Influence the Acute Elevation of Exercise-Induced Cytokines: Double-Blind Crossover Study
title_short The Curcumin Supplementation with Piperine Can Influence the Acute Elevation of Exercise-Induced Cytokines: Double-Blind Crossover Study
title_sort curcumin supplementation with piperine can influence the acute elevation of exercise-induced cytokines: double-blind crossover study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9032800/
https://www.ncbi.nlm.nih.gov/pubmed/35453772
http://dx.doi.org/10.3390/biology11040573
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