SARS-CoV-2 Infects Human ACE2-Negative Endothelial Cells through an α(v)β(3) Integrin-Mediated Endocytosis Even in the Presence of Vaccine-Elicited Neutralizing Antibodies

Integrins represent a gateway of entry for many viruses and the Arg-Gly-Asp (RGD) motif is the smallest sequence necessary for proteins to bind integrins. All Severe Acute Respiratory Syndrome Virus type 2 (SARS-CoV-2) lineages own an RGD motif (aa 403–405) in their receptor binding domain (RBD). We...

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Detalles Bibliográficos
Autores principales: Bugatti, Antonella, Filippini, Federica, Bardelli, Marta, Zani, Alberto, Chiodelli, Paola, Messali, Serena, Caruso, Arnaldo, Caccuri, Francesca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9032829/
https://www.ncbi.nlm.nih.gov/pubmed/35458435
http://dx.doi.org/10.3390/v14040705

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9032829/
https://www.ncbi.nlm.nih.gov/pubmed/35458435
http://dx.doi.org/10.3390/v14040705

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