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Elevation of the Plasma Levels of TNF Receptor 2 in Association with Those of CD25, OX40, and IL-10 and HTLV-1 Proviral Load in Acute Adult T-Cell Leukemia
Adult T-cell leukemia/lymphoma (ATL) cells express TNF receptor type-2 (TNFR2) on their surface and shed its soluble form (sTNFR2). We previously reported that sTNFR2 levels were highly elevated in the plasma of patients with acute ATL. To investigate whether its quantitation would be helpful for th...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9032861/ https://www.ncbi.nlm.nih.gov/pubmed/35458481 http://dx.doi.org/10.3390/v14040751 |
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author | Kato, Megumi Imaizumi, Naoki Tanaka, Reiko Mizuguchi, Mariko Hayashi, Masaki Miyagi, Takashi Uchihara, Junnosuke Ohshiro, Kazuiku Todoroki, Junpei Karube, Kennosuke Masuzaki, Hiroaki Tanaka, Yuetsu Fukushima, Takuya |
author_facet | Kato, Megumi Imaizumi, Naoki Tanaka, Reiko Mizuguchi, Mariko Hayashi, Masaki Miyagi, Takashi Uchihara, Junnosuke Ohshiro, Kazuiku Todoroki, Junpei Karube, Kennosuke Masuzaki, Hiroaki Tanaka, Yuetsu Fukushima, Takuya |
author_sort | Kato, Megumi |
collection | PubMed |
description | Adult T-cell leukemia/lymphoma (ATL) cells express TNF receptor type-2 (TNFR2) on their surface and shed its soluble form (sTNFR2). We previously reported that sTNFR2 levels were highly elevated in the plasma of patients with acute ATL. To investigate whether its quantitation would be helpful for the diagnosis or prediction of the onset of acute ATL, we examined the plasma levels of sTNFR2 in a large number of specimens obtained from a cohort of ATL patients and asymptomatic human T-cell leukemia virus type 1 (HTLV-1) carriers (ACs) and compared them to those of other candidate ATL biomarkers (sCD25, sOX40, and IL-10) by enzyme-linked immunosorbent assays (ELISA) and HTLV-1 proviral loads. We observed that sTNFR2 levels were significantly elevated in acute ATL patients compared to ACs and patients with other types of ATL (chronic, smoldering, and lymphoma). Importantly, sTNFR2 levels were significantly correlated with those of sCD25, sOX40, and IL-10, as well as proviral loads. Thus, the present study confirmed that an increase in plasma sTNFR2 levels is a biomarker for the diagnosis of acute ATL. Examination of plasma sTNFR2 alone or in combination with other ATL biomarkers may be helpful for the diagnosis of acute ATL. |
format | Online Article Text |
id | pubmed-9032861 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-90328612022-04-23 Elevation of the Plasma Levels of TNF Receptor 2 in Association with Those of CD25, OX40, and IL-10 and HTLV-1 Proviral Load in Acute Adult T-Cell Leukemia Kato, Megumi Imaizumi, Naoki Tanaka, Reiko Mizuguchi, Mariko Hayashi, Masaki Miyagi, Takashi Uchihara, Junnosuke Ohshiro, Kazuiku Todoroki, Junpei Karube, Kennosuke Masuzaki, Hiroaki Tanaka, Yuetsu Fukushima, Takuya Viruses Article Adult T-cell leukemia/lymphoma (ATL) cells express TNF receptor type-2 (TNFR2) on their surface and shed its soluble form (sTNFR2). We previously reported that sTNFR2 levels were highly elevated in the plasma of patients with acute ATL. To investigate whether its quantitation would be helpful for the diagnosis or prediction of the onset of acute ATL, we examined the plasma levels of sTNFR2 in a large number of specimens obtained from a cohort of ATL patients and asymptomatic human T-cell leukemia virus type 1 (HTLV-1) carriers (ACs) and compared them to those of other candidate ATL biomarkers (sCD25, sOX40, and IL-10) by enzyme-linked immunosorbent assays (ELISA) and HTLV-1 proviral loads. We observed that sTNFR2 levels were significantly elevated in acute ATL patients compared to ACs and patients with other types of ATL (chronic, smoldering, and lymphoma). Importantly, sTNFR2 levels were significantly correlated with those of sCD25, sOX40, and IL-10, as well as proviral loads. Thus, the present study confirmed that an increase in plasma sTNFR2 levels is a biomarker for the diagnosis of acute ATL. Examination of plasma sTNFR2 alone or in combination with other ATL biomarkers may be helpful for the diagnosis of acute ATL. MDPI 2022-04-03 /pmc/articles/PMC9032861/ /pubmed/35458481 http://dx.doi.org/10.3390/v14040751 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kato, Megumi Imaizumi, Naoki Tanaka, Reiko Mizuguchi, Mariko Hayashi, Masaki Miyagi, Takashi Uchihara, Junnosuke Ohshiro, Kazuiku Todoroki, Junpei Karube, Kennosuke Masuzaki, Hiroaki Tanaka, Yuetsu Fukushima, Takuya Elevation of the Plasma Levels of TNF Receptor 2 in Association with Those of CD25, OX40, and IL-10 and HTLV-1 Proviral Load in Acute Adult T-Cell Leukemia |
title | Elevation of the Plasma Levels of TNF Receptor 2 in Association with Those of CD25, OX40, and IL-10 and HTLV-1 Proviral Load in Acute Adult T-Cell Leukemia |
title_full | Elevation of the Plasma Levels of TNF Receptor 2 in Association with Those of CD25, OX40, and IL-10 and HTLV-1 Proviral Load in Acute Adult T-Cell Leukemia |
title_fullStr | Elevation of the Plasma Levels of TNF Receptor 2 in Association with Those of CD25, OX40, and IL-10 and HTLV-1 Proviral Load in Acute Adult T-Cell Leukemia |
title_full_unstemmed | Elevation of the Plasma Levels of TNF Receptor 2 in Association with Those of CD25, OX40, and IL-10 and HTLV-1 Proviral Load in Acute Adult T-Cell Leukemia |
title_short | Elevation of the Plasma Levels of TNF Receptor 2 in Association with Those of CD25, OX40, and IL-10 and HTLV-1 Proviral Load in Acute Adult T-Cell Leukemia |
title_sort | elevation of the plasma levels of tnf receptor 2 in association with those of cd25, ox40, and il-10 and htlv-1 proviral load in acute adult t-cell leukemia |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9032861/ https://www.ncbi.nlm.nih.gov/pubmed/35458481 http://dx.doi.org/10.3390/v14040751 |
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