Heterogeneity of Mismatch Repair Status and Microsatellite Instability between Primary Tumour and Metastasis and Its Implications for Immunotherapy in Colorectal Cancers

Deficient mismatch repair system (dMMR)/microsatellite instability (MSI) is found in about 5% of metastatic colorectal cancers (mCRCs) with a major therapeutic impact for immune checkpoint inhibitor (ICI) use. We conducted a multicentre study including all consecutive patients with a dMMR/MSI mCRC....

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Detalles Bibliográficos
Autores principales: Evrard, Camille, Messina, Stéphane, Sefrioui, David, Frouin, Éric, Auriault, Marie-Luce, Chautard, Romain, Zaanan, Aziz, Jaffrelot, Marion, De La Fouchardière, Christelle, Aparicio, Thomas, Coriat, Romain, Godet, Julie, Silvain, Christine, Randrian, Violaine, Sabourin, Jean-Christophe, Guimbaud, Rosine, Miquelestorena-Standley, Elodie, Lecomte, Thierry, Moulin, Valérie, Karayan-Tapon, Lucie, Tachon, Gaëlle, Tougeron, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9032866/
https://www.ncbi.nlm.nih.gov/pubmed/35457245
http://dx.doi.org/10.3390/ijms23084427

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