Influence of Parameters on Photodynamic Therapy of Au@TiO(2)–HMME Core-Shell Nanostructures

Photodynamic therapy (PDT) is a promising tumor therapy and has been proven to be an effective, safe and minimally invasive technique. Hematoporphyrin monomethyl ether (HMME) mediated PDT has been used in clinical treatment of port wine stain (PWS) due to its single component, high yield of singlet...

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Autores principales: Wang, Ping, Zhang, Luwei, Zhang, Zhenxi, Wang, Sijia, Yao, Cuiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9032932/
https://www.ncbi.nlm.nih.gov/pubmed/35458066
http://dx.doi.org/10.3390/nano12081358
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author Wang, Ping
Zhang, Luwei
Zhang, Zhenxi
Wang, Sijia
Yao, Cuiping
author_facet Wang, Ping
Zhang, Luwei
Zhang, Zhenxi
Wang, Sijia
Yao, Cuiping
author_sort Wang, Ping
collection PubMed
description Photodynamic therapy (PDT) is a promising tumor therapy and has been proven to be an effective, safe and minimally invasive technique. Hematoporphyrin monomethyl ether (HMME) mediated PDT has been used in clinical treatment of port wine stain (PWS) due to its single component, high yield of singlet oxygen and short light-sensitive period. However, as an amphiphilic photosensitizer, HMME is easy to aggregate due to the presence of a hydrophobic group, which undesirably reduced its generation of singlet oxygen and bioavailability. In this study, we synthesized the stable conjugate of Au@TiO(2) core-shell nanostructure with HMME, and the influence of different factors on PTD efficiency were studied. The results showed that the nanostructure had higher PTD efficiency for KB cells than that of HMME. The irradiation wavelength, gold nanoparticle shape and the shell thickness are all important factors for KB cell PDT.
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spelling pubmed-90329322022-04-23 Influence of Parameters on Photodynamic Therapy of Au@TiO(2)–HMME Core-Shell Nanostructures Wang, Ping Zhang, Luwei Zhang, Zhenxi Wang, Sijia Yao, Cuiping Nanomaterials (Basel) Article Photodynamic therapy (PDT) is a promising tumor therapy and has been proven to be an effective, safe and minimally invasive technique. Hematoporphyrin monomethyl ether (HMME) mediated PDT has been used in clinical treatment of port wine stain (PWS) due to its single component, high yield of singlet oxygen and short light-sensitive period. However, as an amphiphilic photosensitizer, HMME is easy to aggregate due to the presence of a hydrophobic group, which undesirably reduced its generation of singlet oxygen and bioavailability. In this study, we synthesized the stable conjugate of Au@TiO(2) core-shell nanostructure with HMME, and the influence of different factors on PTD efficiency were studied. The results showed that the nanostructure had higher PTD efficiency for KB cells than that of HMME. The irradiation wavelength, gold nanoparticle shape and the shell thickness are all important factors for KB cell PDT. MDPI 2022-04-15 /pmc/articles/PMC9032932/ /pubmed/35458066 http://dx.doi.org/10.3390/nano12081358 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wang, Ping
Zhang, Luwei
Zhang, Zhenxi
Wang, Sijia
Yao, Cuiping
Influence of Parameters on Photodynamic Therapy of Au@TiO(2)–HMME Core-Shell Nanostructures
title Influence of Parameters on Photodynamic Therapy of Au@TiO(2)–HMME Core-Shell Nanostructures
title_full Influence of Parameters on Photodynamic Therapy of Au@TiO(2)–HMME Core-Shell Nanostructures
title_fullStr Influence of Parameters on Photodynamic Therapy of Au@TiO(2)–HMME Core-Shell Nanostructures
title_full_unstemmed Influence of Parameters on Photodynamic Therapy of Au@TiO(2)–HMME Core-Shell Nanostructures
title_short Influence of Parameters on Photodynamic Therapy of Au@TiO(2)–HMME Core-Shell Nanostructures
title_sort influence of parameters on photodynamic therapy of au@tio(2)–hmme core-shell nanostructures
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9032932/
https://www.ncbi.nlm.nih.gov/pubmed/35458066
http://dx.doi.org/10.3390/nano12081358
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