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A Supramolecular Hydrogel Enabled by the Synergy of Hydrophobic Interaction and Quadruple Hydrogen Bonding

The increasing preference for minimally invasive surgery requires novel soft materials that are injectable, with rapid self-healing abilities, and biocompatible. Here, by utilizing the synergetic effect of hydrophobic interaction and quadruple hydrogen bonding, an injectable supramolecular hydrogel...

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Detalles Bibliográficos
Autores principales: Lu, Liangmei, Zhou, Wen, Chen, Zhuzuan, Hu, Yang, Yang, Yu, Zhang, Guangzhao, Yang, Zhuohong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9032949/
https://www.ncbi.nlm.nih.gov/pubmed/35448145
http://dx.doi.org/10.3390/gels8040244
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author Lu, Liangmei
Zhou, Wen
Chen, Zhuzuan
Hu, Yang
Yang, Yu
Zhang, Guangzhao
Yang, Zhuohong
author_facet Lu, Liangmei
Zhou, Wen
Chen, Zhuzuan
Hu, Yang
Yang, Yu
Zhang, Guangzhao
Yang, Zhuohong
author_sort Lu, Liangmei
collection PubMed
description The increasing preference for minimally invasive surgery requires novel soft materials that are injectable, with rapid self-healing abilities, and biocompatible. Here, by utilizing the synergetic effect of hydrophobic interaction and quadruple hydrogen bonding, an injectable supramolecular hydrogel with excellent self-healing ability was synthesized. A unique ABA triblock copolymer was designed containing a central poly(ethylene oxide) block and terminal poly(methylmethacrylate) (PMMA) block, with ureido pyrimidinone (UPy) moieties randomly incorporated (termed MA-UPy-PEO-UPy-MA). The PMMA block could offer a hydrophobic microenvironment for UPy moieties in water and thus boost the corresponding quadruple hydrogen bonding interaction of Upy–Upy dimers. Owing to the synergetic effect of hydrophobicity and quadruple hydrogen bonding interaction, the obtained MA-UPy-PEO-UPy-MA hydrogel exhibited excellent self-healing properties, and injectable capability, as well as superior mechanical strength, and therefore, it holds great promise in tissue engineering applications, including in cell support and drug release.
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spelling pubmed-90329492022-04-23 A Supramolecular Hydrogel Enabled by the Synergy of Hydrophobic Interaction and Quadruple Hydrogen Bonding Lu, Liangmei Zhou, Wen Chen, Zhuzuan Hu, Yang Yang, Yu Zhang, Guangzhao Yang, Zhuohong Gels Article The increasing preference for minimally invasive surgery requires novel soft materials that are injectable, with rapid self-healing abilities, and biocompatible. Here, by utilizing the synergetic effect of hydrophobic interaction and quadruple hydrogen bonding, an injectable supramolecular hydrogel with excellent self-healing ability was synthesized. A unique ABA triblock copolymer was designed containing a central poly(ethylene oxide) block and terminal poly(methylmethacrylate) (PMMA) block, with ureido pyrimidinone (UPy) moieties randomly incorporated (termed MA-UPy-PEO-UPy-MA). The PMMA block could offer a hydrophobic microenvironment for UPy moieties in water and thus boost the corresponding quadruple hydrogen bonding interaction of Upy–Upy dimers. Owing to the synergetic effect of hydrophobicity and quadruple hydrogen bonding interaction, the obtained MA-UPy-PEO-UPy-MA hydrogel exhibited excellent self-healing properties, and injectable capability, as well as superior mechanical strength, and therefore, it holds great promise in tissue engineering applications, including in cell support and drug release. MDPI 2022-04-14 /pmc/articles/PMC9032949/ /pubmed/35448145 http://dx.doi.org/10.3390/gels8040244 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lu, Liangmei
Zhou, Wen
Chen, Zhuzuan
Hu, Yang
Yang, Yu
Zhang, Guangzhao
Yang, Zhuohong
A Supramolecular Hydrogel Enabled by the Synergy of Hydrophobic Interaction and Quadruple Hydrogen Bonding
title A Supramolecular Hydrogel Enabled by the Synergy of Hydrophobic Interaction and Quadruple Hydrogen Bonding
title_full A Supramolecular Hydrogel Enabled by the Synergy of Hydrophobic Interaction and Quadruple Hydrogen Bonding
title_fullStr A Supramolecular Hydrogel Enabled by the Synergy of Hydrophobic Interaction and Quadruple Hydrogen Bonding
title_full_unstemmed A Supramolecular Hydrogel Enabled by the Synergy of Hydrophobic Interaction and Quadruple Hydrogen Bonding
title_short A Supramolecular Hydrogel Enabled by the Synergy of Hydrophobic Interaction and Quadruple Hydrogen Bonding
title_sort supramolecular hydrogel enabled by the synergy of hydrophobic interaction and quadruple hydrogen bonding
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9032949/
https://www.ncbi.nlm.nih.gov/pubmed/35448145
http://dx.doi.org/10.3390/gels8040244
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