A dominant function of LynB kinase in preventing autoimmunity

Here, we report that the LynB splice variant of the Src-family kinase Lyn exerts a dominant immunosuppressive function in vivo, whereas the LynA isoform is uniquely required to restrain autoimmunity in female mice. We used CRISPR-Cas9 gene editing to constrain lyn splicing and expression, generating...

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Detalles Bibliográficos
Autores principales: Brian, Ben F., Sauer, Monica L., Greene, Joseph T., Senevirathne, S. Erandika, Lindstedt, Anders J., Funk, Olivia L., Ruis, Brian L., Ramirez, Luis A., Auger, Jennifer L., Swanson, Whitney L., Nunez, Myra G., Moriarity, Branden S., Lowell, Clifford A., Binstadt, Bryce A., Freedman, Tanya S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9032976/
https://www.ncbi.nlm.nih.gov/pubmed/35452291
http://dx.doi.org/10.1126/sciadv.abj5227

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