Cargando…
HBM4EU Chromates Study: Urinary Metabolomics Study of Workers Exposed to Hexavalent Chromium
Exposure to hexavalent chromium Cr(VI) may occur in several occupational activities, placing workers in many industries at risk for potential related health outcomes. Untargeted metabolomics was applied to investigate changes in metabolic pathways in response to Cr(VI) exposure. We obtained our data...
Autores principales: | , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9032989/ https://www.ncbi.nlm.nih.gov/pubmed/35448548 http://dx.doi.org/10.3390/metabo12040362 |
_version_ | 1784692780759515136 |
---|---|
author | Kozłowska, Lucyna Santonen, Tiina Duca, Radu Corneliu Godderis, Lode Jagiello, Karolina Janasik, Beata Van Nieuwenhuyse, An Poels, Katrien Puzyn, Tomasz Scheepers, Paul T. J. Sijko, Monika Silva, Maria João Sosnowska, Anita Viegas, Susana Verdonck, Jelle Wąsowicz, Wojciech |
author_facet | Kozłowska, Lucyna Santonen, Tiina Duca, Radu Corneliu Godderis, Lode Jagiello, Karolina Janasik, Beata Van Nieuwenhuyse, An Poels, Katrien Puzyn, Tomasz Scheepers, Paul T. J. Sijko, Monika Silva, Maria João Sosnowska, Anita Viegas, Susana Verdonck, Jelle Wąsowicz, Wojciech |
author_sort | Kozłowska, Lucyna |
collection | PubMed |
description | Exposure to hexavalent chromium Cr(VI) may occur in several occupational activities, placing workers in many industries at risk for potential related health outcomes. Untargeted metabolomics was applied to investigate changes in metabolic pathways in response to Cr(VI) exposure. We obtained our data from a study population of 220 male workers with exposure to Cr(VI) and 102 male controls from Belgium, Finland, Poland, Portugal and the Netherlands within the HBM4EU Chromates Study. Urinary metabolite profiles were determined using liquid chromatography mass spectrometry, and differences between post-shift exposed workers and controls were analyzed using principal component analysis. Based on the first two principal components, we observed clustering by industrial chromate application, such as welding, chrome plating, and surface treatment, distinct from controls and not explained by smoking status or alcohol use. The changes in the abundancy of excreted metabolites observed in workers reflect fatty acid and monoamine neurotransmitter metabolism, oxidative modifications of amino acid residues, the excessive formation of abnormal amino acid metabolites and changes in steroid and thyrotropin-releasing hormones. The observed responses could also have resulted from work-related factors other than Cr(VI). Further targeted metabolomics studies are needed to better understand the observed modifications and further explore the suitability of urinary metabolites as early indicators of adverse effects associated with exposure to Cr(VI). |
format | Online Article Text |
id | pubmed-9032989 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-90329892022-04-23 HBM4EU Chromates Study: Urinary Metabolomics Study of Workers Exposed to Hexavalent Chromium Kozłowska, Lucyna Santonen, Tiina Duca, Radu Corneliu Godderis, Lode Jagiello, Karolina Janasik, Beata Van Nieuwenhuyse, An Poels, Katrien Puzyn, Tomasz Scheepers, Paul T. J. Sijko, Monika Silva, Maria João Sosnowska, Anita Viegas, Susana Verdonck, Jelle Wąsowicz, Wojciech Metabolites Article Exposure to hexavalent chromium Cr(VI) may occur in several occupational activities, placing workers in many industries at risk for potential related health outcomes. Untargeted metabolomics was applied to investigate changes in metabolic pathways in response to Cr(VI) exposure. We obtained our data from a study population of 220 male workers with exposure to Cr(VI) and 102 male controls from Belgium, Finland, Poland, Portugal and the Netherlands within the HBM4EU Chromates Study. Urinary metabolite profiles were determined using liquid chromatography mass spectrometry, and differences between post-shift exposed workers and controls were analyzed using principal component analysis. Based on the first two principal components, we observed clustering by industrial chromate application, such as welding, chrome plating, and surface treatment, distinct from controls and not explained by smoking status or alcohol use. The changes in the abundancy of excreted metabolites observed in workers reflect fatty acid and monoamine neurotransmitter metabolism, oxidative modifications of amino acid residues, the excessive formation of abnormal amino acid metabolites and changes in steroid and thyrotropin-releasing hormones. The observed responses could also have resulted from work-related factors other than Cr(VI). Further targeted metabolomics studies are needed to better understand the observed modifications and further explore the suitability of urinary metabolites as early indicators of adverse effects associated with exposure to Cr(VI). MDPI 2022-04-18 /pmc/articles/PMC9032989/ /pubmed/35448548 http://dx.doi.org/10.3390/metabo12040362 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kozłowska, Lucyna Santonen, Tiina Duca, Radu Corneliu Godderis, Lode Jagiello, Karolina Janasik, Beata Van Nieuwenhuyse, An Poels, Katrien Puzyn, Tomasz Scheepers, Paul T. J. Sijko, Monika Silva, Maria João Sosnowska, Anita Viegas, Susana Verdonck, Jelle Wąsowicz, Wojciech HBM4EU Chromates Study: Urinary Metabolomics Study of Workers Exposed to Hexavalent Chromium |
title | HBM4EU Chromates Study: Urinary Metabolomics Study of Workers Exposed to Hexavalent Chromium |
title_full | HBM4EU Chromates Study: Urinary Metabolomics Study of Workers Exposed to Hexavalent Chromium |
title_fullStr | HBM4EU Chromates Study: Urinary Metabolomics Study of Workers Exposed to Hexavalent Chromium |
title_full_unstemmed | HBM4EU Chromates Study: Urinary Metabolomics Study of Workers Exposed to Hexavalent Chromium |
title_short | HBM4EU Chromates Study: Urinary Metabolomics Study of Workers Exposed to Hexavalent Chromium |
title_sort | hbm4eu chromates study: urinary metabolomics study of workers exposed to hexavalent chromium |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9032989/ https://www.ncbi.nlm.nih.gov/pubmed/35448548 http://dx.doi.org/10.3390/metabo12040362 |
work_keys_str_mv | AT kozłowskalucyna hbm4euchromatesstudyurinarymetabolomicsstudyofworkersexposedtohexavalentchromium AT santonentiina hbm4euchromatesstudyurinarymetabolomicsstudyofworkersexposedtohexavalentchromium AT ducaraducorneliu hbm4euchromatesstudyurinarymetabolomicsstudyofworkersexposedtohexavalentchromium AT godderislode hbm4euchromatesstudyurinarymetabolomicsstudyofworkersexposedtohexavalentchromium AT jagiellokarolina hbm4euchromatesstudyurinarymetabolomicsstudyofworkersexposedtohexavalentchromium AT janasikbeata hbm4euchromatesstudyurinarymetabolomicsstudyofworkersexposedtohexavalentchromium AT vannieuwenhuysean hbm4euchromatesstudyurinarymetabolomicsstudyofworkersexposedtohexavalentchromium AT poelskatrien hbm4euchromatesstudyurinarymetabolomicsstudyofworkersexposedtohexavalentchromium AT puzyntomasz hbm4euchromatesstudyurinarymetabolomicsstudyofworkersexposedtohexavalentchromium AT scheeperspaultj hbm4euchromatesstudyurinarymetabolomicsstudyofworkersexposedtohexavalentchromium AT sijkomonika hbm4euchromatesstudyurinarymetabolomicsstudyofworkersexposedtohexavalentchromium AT silvamariajoao hbm4euchromatesstudyurinarymetabolomicsstudyofworkersexposedtohexavalentchromium AT sosnowskaanita hbm4euchromatesstudyurinarymetabolomicsstudyofworkersexposedtohexavalentchromium AT viegassusana hbm4euchromatesstudyurinarymetabolomicsstudyofworkersexposedtohexavalentchromium AT verdonckjelle hbm4euchromatesstudyurinarymetabolomicsstudyofworkersexposedtohexavalentchromium AT wasowiczwojciech hbm4euchromatesstudyurinarymetabolomicsstudyofworkersexposedtohexavalentchromium AT hbm4euchromatesstudyurinarymetabolomicsstudyofworkersexposedtohexavalentchromium AT hbm4euchromatesstudyurinarymetabolomicsstudyofworkersexposedtohexavalentchromium |