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MafA Regulation in β-Cells: From Transcriptional to Post-Translational Mechanisms
β-cells are insulin-producing cells in the pancreas that maintain euglycemic conditions. Pancreatic β-cell maturity and function are regulated by a variety of transcription factors that enable the adequate expression of the cellular machinery involved in nutrient sensing and commensurate insulin sec...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9033020/ https://www.ncbi.nlm.nih.gov/pubmed/35454124 http://dx.doi.org/10.3390/biom12040535 |
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author | Liang, Jiani Chirikjian, Margot Pajvani, Utpal B. Bartolomé, Alberto |
author_facet | Liang, Jiani Chirikjian, Margot Pajvani, Utpal B. Bartolomé, Alberto |
author_sort | Liang, Jiani |
collection | PubMed |
description | β-cells are insulin-producing cells in the pancreas that maintain euglycemic conditions. Pancreatic β-cell maturity and function are regulated by a variety of transcription factors that enable the adequate expression of the cellular machinery involved in nutrient sensing and commensurate insulin secretion. One of the key factors in this regulation is MAF bZIP transcription factor A (MafA). MafA expression is decreased in type 2 diabetes, contributing to β-cell dysfunction and disease progression. The molecular biology underlying MafA is complex, with numerous transcriptional and post-translational regulatory nodes. Understanding these complexities may uncover potential therapeutic targets to ameliorate β-cell dysfunction. This article will summarize the role of MafA in normal β-cell function and disease, with a special focus on known transcriptional and post-translational regulators of MafA expression |
format | Online Article Text |
id | pubmed-9033020 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-90330202022-04-23 MafA Regulation in β-Cells: From Transcriptional to Post-Translational Mechanisms Liang, Jiani Chirikjian, Margot Pajvani, Utpal B. Bartolomé, Alberto Biomolecules Review β-cells are insulin-producing cells in the pancreas that maintain euglycemic conditions. Pancreatic β-cell maturity and function are regulated by a variety of transcription factors that enable the adequate expression of the cellular machinery involved in nutrient sensing and commensurate insulin secretion. One of the key factors in this regulation is MAF bZIP transcription factor A (MafA). MafA expression is decreased in type 2 diabetes, contributing to β-cell dysfunction and disease progression. The molecular biology underlying MafA is complex, with numerous transcriptional and post-translational regulatory nodes. Understanding these complexities may uncover potential therapeutic targets to ameliorate β-cell dysfunction. This article will summarize the role of MafA in normal β-cell function and disease, with a special focus on known transcriptional and post-translational regulators of MafA expression MDPI 2022-03-31 /pmc/articles/PMC9033020/ /pubmed/35454124 http://dx.doi.org/10.3390/biom12040535 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Liang, Jiani Chirikjian, Margot Pajvani, Utpal B. Bartolomé, Alberto MafA Regulation in β-Cells: From Transcriptional to Post-Translational Mechanisms |
title | MafA Regulation in β-Cells: From Transcriptional to Post-Translational Mechanisms |
title_full | MafA Regulation in β-Cells: From Transcriptional to Post-Translational Mechanisms |
title_fullStr | MafA Regulation in β-Cells: From Transcriptional to Post-Translational Mechanisms |
title_full_unstemmed | MafA Regulation in β-Cells: From Transcriptional to Post-Translational Mechanisms |
title_short | MafA Regulation in β-Cells: From Transcriptional to Post-Translational Mechanisms |
title_sort | mafa regulation in β-cells: from transcriptional to post-translational mechanisms |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9033020/ https://www.ncbi.nlm.nih.gov/pubmed/35454124 http://dx.doi.org/10.3390/biom12040535 |
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