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Association of Non-Alcoholic Fatty Liver Disease and Hepatic Fibrosis with Epicardial Adipose Tissue Volume and Atrial Deformation Mechanics in a Large Asian Population Free from Clinical Heart Failure

Non-alcoholic fatty liver disease (NAFLD) and cardiovascular disease share several cardiometabolic risk factors. Excessive visceral fat can manifest as ectopic fat depots over vital organs, such as the heart and liver. This study assessed the associations of NAFLD and liver fibrosis with cardiac str...

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Autores principales: Lai, Yau-Huei, Su, Cheng-Huang, Hung, Ta-Chuan, Yun, Chun-Ho, Tsai, Cheng-Ting, Yeh, Hung-I, Hung, Chung-Lieh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9033151/
https://www.ncbi.nlm.nih.gov/pubmed/35453964
http://dx.doi.org/10.3390/diagnostics12040916
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author Lai, Yau-Huei
Su, Cheng-Huang
Hung, Ta-Chuan
Yun, Chun-Ho
Tsai, Cheng-Ting
Yeh, Hung-I
Hung, Chung-Lieh
author_facet Lai, Yau-Huei
Su, Cheng-Huang
Hung, Ta-Chuan
Yun, Chun-Ho
Tsai, Cheng-Ting
Yeh, Hung-I
Hung, Chung-Lieh
author_sort Lai, Yau-Huei
collection PubMed
description Non-alcoholic fatty liver disease (NAFLD) and cardiovascular disease share several cardiometabolic risk factors. Excessive visceral fat can manifest as ectopic fat depots over vital organs, such as the heart and liver. This study assessed the associations of NAFLD and liver fibrosis with cardiac structural and functional disturbances. We assessed 2161 participants using ultrasound, and categorized them as per the NAFLD Fibrosis Score into three groups: (1) non-fatty liver; (2) fatty liver with low fibrosis score; and (3) fatty liver with high fibrosis score. Epicardial fat volume (EFV) was measured through multidetector computed tomography. All participants underwent echocardiographic study, including tissue Doppler-based E/e’ ratio and speckle tracking-based left ventricular global longitudinal strain, peak atrial longitudinal strain (PALS), and atrial longitudinal strain rates during systolic, early and late-diastolic phases (ALSR(syst), ALSR(early). ALSR(l)(ate)). Larger EFV, decreased e’ velocity, PALS, ALSR(syst), and ALSR(early), along with elevated E/e’ ratio, were seen in all groups, especially in those with high fibrosis scores. After multivariate adjustment for traditional risk factors and EFV, fibrosis scores remained significantly associated with elevated E/e’ ratio, LA stiffness, and decreased PALS (β: 0.06, 1.4, −0.01, all p < 0.05). Thus, NAFLD is associated with LV diastolic dysfunction and subclinical changes in LA contractile mechanics.
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spelling pubmed-90331512022-04-23 Association of Non-Alcoholic Fatty Liver Disease and Hepatic Fibrosis with Epicardial Adipose Tissue Volume and Atrial Deformation Mechanics in a Large Asian Population Free from Clinical Heart Failure Lai, Yau-Huei Su, Cheng-Huang Hung, Ta-Chuan Yun, Chun-Ho Tsai, Cheng-Ting Yeh, Hung-I Hung, Chung-Lieh Diagnostics (Basel) Article Non-alcoholic fatty liver disease (NAFLD) and cardiovascular disease share several cardiometabolic risk factors. Excessive visceral fat can manifest as ectopic fat depots over vital organs, such as the heart and liver. This study assessed the associations of NAFLD and liver fibrosis with cardiac structural and functional disturbances. We assessed 2161 participants using ultrasound, and categorized them as per the NAFLD Fibrosis Score into three groups: (1) non-fatty liver; (2) fatty liver with low fibrosis score; and (3) fatty liver with high fibrosis score. Epicardial fat volume (EFV) was measured through multidetector computed tomography. All participants underwent echocardiographic study, including tissue Doppler-based E/e’ ratio and speckle tracking-based left ventricular global longitudinal strain, peak atrial longitudinal strain (PALS), and atrial longitudinal strain rates during systolic, early and late-diastolic phases (ALSR(syst), ALSR(early). ALSR(l)(ate)). Larger EFV, decreased e’ velocity, PALS, ALSR(syst), and ALSR(early), along with elevated E/e’ ratio, were seen in all groups, especially in those with high fibrosis scores. After multivariate adjustment for traditional risk factors and EFV, fibrosis scores remained significantly associated with elevated E/e’ ratio, LA stiffness, and decreased PALS (β: 0.06, 1.4, −0.01, all p < 0.05). Thus, NAFLD is associated with LV diastolic dysfunction and subclinical changes in LA contractile mechanics. MDPI 2022-04-06 /pmc/articles/PMC9033151/ /pubmed/35453964 http://dx.doi.org/10.3390/diagnostics12040916 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lai, Yau-Huei
Su, Cheng-Huang
Hung, Ta-Chuan
Yun, Chun-Ho
Tsai, Cheng-Ting
Yeh, Hung-I
Hung, Chung-Lieh
Association of Non-Alcoholic Fatty Liver Disease and Hepatic Fibrosis with Epicardial Adipose Tissue Volume and Atrial Deformation Mechanics in a Large Asian Population Free from Clinical Heart Failure
title Association of Non-Alcoholic Fatty Liver Disease and Hepatic Fibrosis with Epicardial Adipose Tissue Volume and Atrial Deformation Mechanics in a Large Asian Population Free from Clinical Heart Failure
title_full Association of Non-Alcoholic Fatty Liver Disease and Hepatic Fibrosis with Epicardial Adipose Tissue Volume and Atrial Deformation Mechanics in a Large Asian Population Free from Clinical Heart Failure
title_fullStr Association of Non-Alcoholic Fatty Liver Disease and Hepatic Fibrosis with Epicardial Adipose Tissue Volume and Atrial Deformation Mechanics in a Large Asian Population Free from Clinical Heart Failure
title_full_unstemmed Association of Non-Alcoholic Fatty Liver Disease and Hepatic Fibrosis with Epicardial Adipose Tissue Volume and Atrial Deformation Mechanics in a Large Asian Population Free from Clinical Heart Failure
title_short Association of Non-Alcoholic Fatty Liver Disease and Hepatic Fibrosis with Epicardial Adipose Tissue Volume and Atrial Deformation Mechanics in a Large Asian Population Free from Clinical Heart Failure
title_sort association of non-alcoholic fatty liver disease and hepatic fibrosis with epicardial adipose tissue volume and atrial deformation mechanics in a large asian population free from clinical heart failure
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9033151/
https://www.ncbi.nlm.nih.gov/pubmed/35453964
http://dx.doi.org/10.3390/diagnostics12040916
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