Electrochemical synthesis of quinazolinone via I(2)-catalyzed tandem oxidation in aqueous solution

The development of protocols for synthesizing quinazolinones using biocompatible catalysts in aqueous medium will help to resolve the difficulties of using green and sustainable chemistry for their synthesis. Herein, using I(2) in coordination with electrochemical synthesis induced a C–H oxidation r...

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Detalles Bibliográficos
Autores principales: Hou, Huiqing, Ma, Xinhua, Lin, Yingying, Lin, Jin, Sun, Weiming, Wang, Lei, Xu, Xiuzhi, Ke, Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9033184/
https://www.ncbi.nlm.nih.gov/pubmed/35480173
http://dx.doi.org/10.1039/d1ra02706a
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author Hou, Huiqing
Ma, Xinhua
Lin, Yingying
Lin, Jin
Sun, Weiming
Wang, Lei
Xu, Xiuzhi
Ke, Fang
author_facet Hou, Huiqing
Ma, Xinhua
Lin, Yingying
Lin, Jin
Sun, Weiming
Wang, Lei
Xu, Xiuzhi
Ke, Fang
author_sort Hou, Huiqing
collection PubMed
description The development of protocols for synthesizing quinazolinones using biocompatible catalysts in aqueous medium will help to resolve the difficulties of using green and sustainable chemistry for their synthesis. Herein, using I(2) in coordination with electrochemical synthesis induced a C–H oxidation reaction which is reported when using water as the environmentally friendly solvent to access a broad range of quinazolinones at room temperature. The reaction mechanism strongly showed that I(2) cooperates electrochemically promoted the oxidation of alcohols, then effectively cyclizing amides to various quinazolinones.
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spelling pubmed-90331842022-04-26 Electrochemical synthesis of quinazolinone via I(2)-catalyzed tandem oxidation in aqueous solution Hou, Huiqing Ma, Xinhua Lin, Yingying Lin, Jin Sun, Weiming Wang, Lei Xu, Xiuzhi Ke, Fang RSC Adv Chemistry The development of protocols for synthesizing quinazolinones using biocompatible catalysts in aqueous medium will help to resolve the difficulties of using green and sustainable chemistry for their synthesis. Herein, using I(2) in coordination with electrochemical synthesis induced a C–H oxidation reaction which is reported when using water as the environmentally friendly solvent to access a broad range of quinazolinones at room temperature. The reaction mechanism strongly showed that I(2) cooperates electrochemically promoted the oxidation of alcohols, then effectively cyclizing amides to various quinazolinones. The Royal Society of Chemistry 2021-05-17 /pmc/articles/PMC9033184/ /pubmed/35480173 http://dx.doi.org/10.1039/d1ra02706a Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Hou, Huiqing
Ma, Xinhua
Lin, Yingying
Lin, Jin
Sun, Weiming
Wang, Lei
Xu, Xiuzhi
Ke, Fang
Electrochemical synthesis of quinazolinone via I(2)-catalyzed tandem oxidation in aqueous solution
title Electrochemical synthesis of quinazolinone via I(2)-catalyzed tandem oxidation in aqueous solution
title_full Electrochemical synthesis of quinazolinone via I(2)-catalyzed tandem oxidation in aqueous solution
title_fullStr Electrochemical synthesis of quinazolinone via I(2)-catalyzed tandem oxidation in aqueous solution
title_full_unstemmed Electrochemical synthesis of quinazolinone via I(2)-catalyzed tandem oxidation in aqueous solution
title_short Electrochemical synthesis of quinazolinone via I(2)-catalyzed tandem oxidation in aqueous solution
title_sort electrochemical synthesis of quinazolinone via i(2)-catalyzed tandem oxidation in aqueous solution
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9033184/
https://www.ncbi.nlm.nih.gov/pubmed/35480173
http://dx.doi.org/10.1039/d1ra02706a
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