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Case Report and Literature Review: Bacterial Meningoencephalitis or Not? Naegleria fowleri Related Primary Amoebic Meningoencephalitis in China

In China, a 9-year-old boy was transferred to the hospital with fever, vomiting, and headache. The disease rapidly deteriorated into vague consciousness. Applying conventional clinical examinations such as blood and cerebrospinal fluid (CSF) tests, the diagnosis of bacterial meningoencephalitis was...

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Autores principales: Zhou, Wenjuan, Ouyang, Yuzhen, Zhang, Di, Liao, Sheng, Liang, Hui, Zhao, Lingling, Chen, Chunyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9033202/
https://www.ncbi.nlm.nih.gov/pubmed/35463884
http://dx.doi.org/10.3389/fped.2022.785735
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author Zhou, Wenjuan
Ouyang, Yuzhen
Zhang, Di
Liao, Sheng
Liang, Hui
Zhao, Lingling
Chen, Chunyuan
author_facet Zhou, Wenjuan
Ouyang, Yuzhen
Zhang, Di
Liao, Sheng
Liang, Hui
Zhao, Lingling
Chen, Chunyuan
author_sort Zhou, Wenjuan
collection PubMed
description In China, a 9-year-old boy was transferred to the hospital with fever, vomiting, and headache. The disease rapidly deteriorated into vague consciousness. Applying conventional clinical examinations such as blood and cerebrospinal fluid (CSF) tests, the diagnosis of bacterial meningoencephalitis was first drawn, and expectant treatments were adopted immediately. However, the symptoms did not alleviate, adversely, this boy died 3 days after admission. Considering the skeptical points of the duration, such as the unknown infectious bacteria and the pathogen invasion path, blood and CSF samples were then sent for metagenomic next-generation sequencing (mNGS) to ascertain the cause of death. The 42,899 and 1,337 specific sequences of N. fowleri were detected by mNGS in the CSF sample and the blood sample, respectively. PCR results and pathological smear subsequently confirmed the mNGS detection. The patient was finally diagnosed as primary amoebic meningoencephalitis. Besides, in this article, 15 similar child infection cases in the past 10 years are summarized and analyzed to promote the early diagnosis of this rare disease.
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spelling pubmed-90332022022-04-23 Case Report and Literature Review: Bacterial Meningoencephalitis or Not? Naegleria fowleri Related Primary Amoebic Meningoencephalitis in China Zhou, Wenjuan Ouyang, Yuzhen Zhang, Di Liao, Sheng Liang, Hui Zhao, Lingling Chen, Chunyuan Front Pediatr Pediatrics In China, a 9-year-old boy was transferred to the hospital with fever, vomiting, and headache. The disease rapidly deteriorated into vague consciousness. Applying conventional clinical examinations such as blood and cerebrospinal fluid (CSF) tests, the diagnosis of bacterial meningoencephalitis was first drawn, and expectant treatments were adopted immediately. However, the symptoms did not alleviate, adversely, this boy died 3 days after admission. Considering the skeptical points of the duration, such as the unknown infectious bacteria and the pathogen invasion path, blood and CSF samples were then sent for metagenomic next-generation sequencing (mNGS) to ascertain the cause of death. The 42,899 and 1,337 specific sequences of N. fowleri were detected by mNGS in the CSF sample and the blood sample, respectively. PCR results and pathological smear subsequently confirmed the mNGS detection. The patient was finally diagnosed as primary amoebic meningoencephalitis. Besides, in this article, 15 similar child infection cases in the past 10 years are summarized and analyzed to promote the early diagnosis of this rare disease. Frontiers Media S.A. 2022-04-08 /pmc/articles/PMC9033202/ /pubmed/35463884 http://dx.doi.org/10.3389/fped.2022.785735 Text en Copyright © 2022 Zhou, Ouyang, Zhang, Liao, Liang, Zhao and Chen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Zhou, Wenjuan
Ouyang, Yuzhen
Zhang, Di
Liao, Sheng
Liang, Hui
Zhao, Lingling
Chen, Chunyuan
Case Report and Literature Review: Bacterial Meningoencephalitis or Not? Naegleria fowleri Related Primary Amoebic Meningoencephalitis in China
title Case Report and Literature Review: Bacterial Meningoencephalitis or Not? Naegleria fowleri Related Primary Amoebic Meningoencephalitis in China
title_full Case Report and Literature Review: Bacterial Meningoencephalitis or Not? Naegleria fowleri Related Primary Amoebic Meningoencephalitis in China
title_fullStr Case Report and Literature Review: Bacterial Meningoencephalitis or Not? Naegleria fowleri Related Primary Amoebic Meningoencephalitis in China
title_full_unstemmed Case Report and Literature Review: Bacterial Meningoencephalitis or Not? Naegleria fowleri Related Primary Amoebic Meningoencephalitis in China
title_short Case Report and Literature Review: Bacterial Meningoencephalitis or Not? Naegleria fowleri Related Primary Amoebic Meningoencephalitis in China
title_sort case report and literature review: bacterial meningoencephalitis or not? naegleria fowleri related primary amoebic meningoencephalitis in china
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9033202/
https://www.ncbi.nlm.nih.gov/pubmed/35463884
http://dx.doi.org/10.3389/fped.2022.785735
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