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Postnatal Smad3 Inactivation in Murine Smooth Muscle Cells Elicits a Temporally and Regionally Distinct Transcriptional Response

Heterozygous, loss of function mutations in positive regulators of the Transforming Growth Factor-β (TGF-β) pathway cause hereditary forms of thoracic aortic aneurysm. It is unclear whether and how the initial signaling deficiency triggers secondary signaling upregulation in the remaining functional...

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Detalles Bibliográficos
Autores principales:	Bramel, Emily E., Creamer, Tyler J., Saqib, Muzna, Camejo Nunez, Wendy A., Bagirzadeh, Rustam, Roker, LaToya Ann, Goff, Loyal A., MacFarlane, Elena Gallo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Cardiovascular Medicine
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9033237/ https://www.ncbi.nlm.nih.gov/pubmed/35463747 http://dx.doi.org/10.3389/fcvm.2022.826495

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