Cargando…

Subcellular Proteome Analysis Reveals Apoptotic Vulnerability of T-Cell Acute Lymphoblastic Leukemia

Targeting death receptor-mediated apoptosis in T-cell acute lymphoblastic leukemia (T-ALL), an aggressive disease with poor prognosis, is hindered by the inherent resistance of primary leukemia cells. Knowledge on therapeutic vulnerabilities in these malignant cells will provide opportunities for de...

Descripción completa

Detalles Bibliográficos
Autores principales:	Song, Xiaolei, Wu, Xiaojing, Zhang, Zihan, Cui, Zhangxiu, Zheng, Yong, Sun, Jian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9033339/ https://www.ncbi.nlm.nih.gov/pubmed/35463978 http://dx.doi.org/10.1155/2022/5504475

Ejemplares similares

Dual Targeting of Apoptotic and Signaling Pathways in T-Lineage Acute Lymphoblastic Leukemia
por: Saygin, Caner, et al.
Publicado: (2023)

Proteomics in Childhood Acute Lymphoblastic Leukemia: Challenges and Opportunities
por: Kourti, Maria, et al.
Publicado: (2023)

The Classical Apoptotic Adaptor FADD Regulates Glycolytic Capacity in Acute Lymphoblastic Leukemia
por: Zhou, Wenzhao, et al.
Publicado: (2022)

P330: PROTEOMIC PROFILING UNCOVERS THERAPEUTIC VULNERABILITIES FOR TCF3 TRANSLOCATED B-CELL ACUTE LYMPHOBLASTIC LEUKEMIAS
por: Hasselmann, Rebecca, et al.
Publicado: (2023)

Proteomics of resistance to Notch1 inhibition in acute lymphoblastic leukemia reveals targetable kinase signatures
por: Franciosa, Giulia, et al.
Publicado: (2021)

Phosphoproteomic Analysis Reveals a Different Proteomic Profile in Pediatric Patients With T-Cell Lymphoblastic Lymphoma or T-Cell Acute Lymphoblastic Leukemia
por: Veltri, Giulia, et al.
Publicado: (2022)

Idasanutlin and navitoclax induce synergistic apoptotic cell death in T-cell acute lymphoblastic leukemia
por: Johansson, Kimberly B., et al.
Publicado: (2023)

Hypoxic, glycolytic metabolism is a vulnerability of B-acute lymphoblastic leukemia-initiating cells
por: Morris, Vivian, et al.
Publicado: (2022)

PB1749: APOPTOTIC EFFECT OF FLUMATINIB COMBINED WITH BCL2 INHIBITOR ON PH+ B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA
por: Gu, Y., et al.
Publicado: (2022)

Acute lymphoblastic leukemia
por: Schrappe, Martin
Publicado: (2018)

Focused CRISPR-Cas9 genetic screening reveals USO1 as a vulnerability in B-cell acute lymphoblastic leukemia
por: Jaiswal, Amit Kumar, et al.
Publicado: (2021)

P323: UNCOVERING SUBCLONAL METABOLIC VULNERABILITIES IN ACUTE LYMPHOBLASTIC LEUKEMIA AT SINGLE CELL RESOLUTION
por: Mönnig, Maximilian, et al.
Publicado: (2023)

A comparative proteomic study of plasma in Colombian childhood acute lymphoblastic leukemia
por: Calderon-Rodríguez, Sandra Isabel, et al.
Publicado: (2019)

Role of apoptotic markers in paediatric acute lymphoblastic leukaemia
por: Kapoor, Gauri, et al.
Publicado: (2018)

MEK Inhibitors Potentiate Dexamethasone Lethality in Acute Lymphoblastic Leukemia Cells through the Pro-apoptotic Molecule BIM
por: Rambal, Anila A., et al.
Publicado: (2009)

Enhanced levels of the apoptotic BAX/BCL-2 ratio in children with acute lymphoblastic leukemia and high-risk features
por: Kaparou, Maria, et al.
Publicado: (2013)

The KRAS-G12D mutation induces metabolic vulnerability in B-cell acute lymphoblastic leukemia
por: Xu, Yan, et al.
Publicado: (2022)

Genome-wide CRISPR screens identify ferroptosis as a novel therapeutic vulnerability in acute lymphoblastic leukemia
por: Lalonde, Marie-Eve, et al.
Publicado: (2022)

Acute lymphoblastic leukemia in adults
por: Ribera, Josep-Maria
Publicado: (2011)

Pediatric acute lymphoblastic leukemia
por: Inaba, Hiroto, et al.
Publicado: (2020)

Altered proteome of high-density lipoproteins from paediatric acute lymphoblastic leukemia survivors
por: Fournier, Maryse, et al.
Publicado: (2019)

Proteomic profiling of plasma exosomes from patients with B-cell acute lymphoblastic leukemia
por: Zhu, Shicong, et al.
Publicado: (2022)

Recent advances on blinatumomab for acute lymphoblastic leukemia
por: Zhao, Juanjuan, et al.
Publicado: (2019)

Spatial-proteomics reveals phospho-signaling dynamics at subcellular resolution
por: Martinez-Val, Ana, et al.
Publicado: (2021)

Proteomic profile of pre - B2 lymphoblasts from children with acute lymphoblastic leukemia (ALL) in relation with the translocation (12; 21)
por: Costa, Odile, et al.
Publicado: (2014)

Novel gene signature reveals prognostic model in acute lymphoblastic leukemia
por: Chen, Panpan, et al.
Publicado: (2022)

HSP90 inhibition leads to degradation of the TYK2 kinase and apoptotic cell death in T-cell acute lymphoblastic leukemia
por: Akahane, Koshi, et al.
Publicado: (2015)

A p53-regulated apoptotic gene signature predicts treatment response and outcome in pediatric acute lymphoblastic leukemia
por: Bainer, Russell O, et al.
Publicado: (2017)

MCL-1 Inhibition Overcomes Anti-apoptotic Adaptation to Targeted Therapies in B-Cell Precursor Acute Lymphoblastic Leukemia
por: Manzano-Muñoz, Albert, et al.
Publicado: (2021)

Quantifying subcellular dynamics in apoptotic cells with two-dimensional Gabor filters
por: Pasternack, Robert M., et al.
Publicado: (2010)

Glucocorticoid Resistant Pediatric Acute Lymphoblastic Leukemia Samples Display Altered Splicing Profile and Vulnerability to Spliceosome Modulation
por: Sciarrillo, Rocco, et al.
Publicado: (2020)

Regulome analysis in B-acute lymphoblastic leukemia exposes Core Binding Factor addiction as a therapeutic vulnerability
por: Wray, Jason P., et al.
Publicado: (2022)

Venetoclax for Children and Adolescents with Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma
por: Gibson, Amber, et al.
Publicado: (2021)

Current Use of Asparaginase in Acute Lymphoblastic Leukemia/Lymphoblastic Lymphoma
por: Maese, Luke, et al.
Publicado: (2022)

Application of Glutamine-enriched nutrition therapy in childhood acute lymphoblastic leukemia
por: Han, Yueqin, et al.
Publicado: (2016)

Proteomic analysis of cerebrospinal fluid in pediatric acute lymphoblastic leukemia patients: a pilot study
por: Guo, Linghong, et al.
Publicado: (2019)

PDX models reflect the proteome landscape of pediatric acute lymphoblastic leukemia but divert in select pathways
por: Uzozie, Anuli C., et al.
Publicado: (2021)

Leukemia-Initiating Cells in T-Cell Acute Lymphoblastic Leukemia
por: Tan, Shi Hao, et al.
Publicado: (2017)

Acute lymphoblastic leukemia: age and biology
por: Foà, Robin
Publicado: (2011)

Pathogenesis and prognostication in acute lymphoblastic leukemia
por: Zuckerman, Tsila, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_pcsh0hp3sgs2qmj0ndelt5piba