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The Role of Zinc Finger Proteins in Various Oral Conditions
The zinc finger proteins (ZNFs) are essential transcription factors, and the genes encoding them constitute about 3% of the entire human genome. They are involved in the development of several tissues, and any alterations in their structure may promote chronic conditions like diabetes and tumorigene...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9033369/ https://www.ncbi.nlm.nih.gov/pubmed/35463825 http://dx.doi.org/10.1155/2022/4612054 |
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author | Agnihotri, Rupali Gaur, Sumit |
author_facet | Agnihotri, Rupali Gaur, Sumit |
author_sort | Agnihotri, Rupali |
collection | PubMed |
description | The zinc finger proteins (ZNFs) are essential transcription factors, and the genes encoding them constitute about 3% of the entire human genome. They are involved in the development of several tissues, and any alterations in their structure may promote chronic conditions like diabetes and tumorigenesis. Lately, their role in the development, progression, and metastasis of Oral Squamous Cell Carcinoma (OSCC), Epithelial Dysplasia, Oral Lichen Planus, and Periodontitis has been found. The present review aims to describe their role in various oral conditions. Electronic databases like Medline (PubMed) and Scopus were searched for original studies related to the role of ZNFs in various oral conditions. It yielded 48 studies included in the review. It was found that the ZNFs influenced chronic conditions like Oral Cancer and Periodontitis. They act both as tumor suppressors and oncogenes and have an anti-inflammatory effect. The knowledge from the present review may be utilized in designing drugs that prevent unusual expression of specific ZNFs. Besides, they may be applied as prognostic markers due to their high expression specificity in some tumors. |
format | Online Article Text |
id | pubmed-9033369 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-90333692022-04-23 The Role of Zinc Finger Proteins in Various Oral Conditions Agnihotri, Rupali Gaur, Sumit ScientificWorldJournal Review Article The zinc finger proteins (ZNFs) are essential transcription factors, and the genes encoding them constitute about 3% of the entire human genome. They are involved in the development of several tissues, and any alterations in their structure may promote chronic conditions like diabetes and tumorigenesis. Lately, their role in the development, progression, and metastasis of Oral Squamous Cell Carcinoma (OSCC), Epithelial Dysplasia, Oral Lichen Planus, and Periodontitis has been found. The present review aims to describe their role in various oral conditions. Electronic databases like Medline (PubMed) and Scopus were searched for original studies related to the role of ZNFs in various oral conditions. It yielded 48 studies included in the review. It was found that the ZNFs influenced chronic conditions like Oral Cancer and Periodontitis. They act both as tumor suppressors and oncogenes and have an anti-inflammatory effect. The knowledge from the present review may be utilized in designing drugs that prevent unusual expression of specific ZNFs. Besides, they may be applied as prognostic markers due to their high expression specificity in some tumors. Hindawi 2022-04-15 /pmc/articles/PMC9033369/ /pubmed/35463825 http://dx.doi.org/10.1155/2022/4612054 Text en Copyright © 2022 Rupali Agnihotri and Sumit Gaur. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Agnihotri, Rupali Gaur, Sumit The Role of Zinc Finger Proteins in Various Oral Conditions |
title | The Role of Zinc Finger Proteins in Various Oral Conditions |
title_full | The Role of Zinc Finger Proteins in Various Oral Conditions |
title_fullStr | The Role of Zinc Finger Proteins in Various Oral Conditions |
title_full_unstemmed | The Role of Zinc Finger Proteins in Various Oral Conditions |
title_short | The Role of Zinc Finger Proteins in Various Oral Conditions |
title_sort | role of zinc finger proteins in various oral conditions |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9033369/ https://www.ncbi.nlm.nih.gov/pubmed/35463825 http://dx.doi.org/10.1155/2022/4612054 |
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