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Chemoselective bioconjugation based on modular click chemistry with 4-halocoumarins and aryl sulfonates
We report chemoselective and modular peptide bioconjugation using stoichiometric amounts of 4-halocoumarin and arylsulfonate agents that undergo metal-free C(sp(2))-heteroatom bond formation at micromolar concentrations. The underlying ipso-substitution click chemistry is irreversible and generates...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9033492/ https://www.ncbi.nlm.nih.gov/pubmed/35478620 http://dx.doi.org/10.1039/d1ra03271b |