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Chemoselective bioconjugation based on modular click chemistry with 4-halocoumarins and aryl sulfonates

We report chemoselective and modular peptide bioconjugation using stoichiometric amounts of 4-halocoumarin and arylsulfonate agents that undergo metal-free C(sp(2))-heteroatom bond formation at micromolar concentrations. The underlying ipso-substitution click chemistry is irreversible and generates...

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Detalles Bibliográficos
Autores principales: Thanzeel, F. Yushra, Wolf, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9033492/
https://www.ncbi.nlm.nih.gov/pubmed/35478620
http://dx.doi.org/10.1039/d1ra03271b

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