Me(3)SI-promoted chemoselective deacetylation: a general and mild protocol

A Me(3)SI-mediated simple and efficient protocol for the chemoselective deprotection of acetyl groups has been developed via employing KMnO(4) as an additive. This chemoselective deacetylation is amenable to a wide range of substrates, tolerating diverse and sensitive functional groups in carbohydra...

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Detalles Bibliográficos
Autores principales: Gurawa, Aakanksha, Kumar, Manoj, Kashyap, Sudhir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9033574/
https://www.ncbi.nlm.nih.gov/pubmed/35478635
http://dx.doi.org/10.1039/d1ra03209g
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author Gurawa, Aakanksha
Kumar, Manoj
Kashyap, Sudhir
author_facet Gurawa, Aakanksha
Kumar, Manoj
Kashyap, Sudhir
author_sort Gurawa, Aakanksha
collection PubMed
description A Me(3)SI-mediated simple and efficient protocol for the chemoselective deprotection of acetyl groups has been developed via employing KMnO(4) as an additive. This chemoselective deacetylation is amenable to a wide range of substrates, tolerating diverse and sensitive functional groups in carbohydrates, amino acids, natural products, heterocycles, and general scaffolds. The protocol is attractive because it uses an environmentally benign reagent system to perform quantitative and clean transformations under ambient conditions.
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spelling pubmed-90335742022-04-26 Me(3)SI-promoted chemoselective deacetylation: a general and mild protocol Gurawa, Aakanksha Kumar, Manoj Kashyap, Sudhir RSC Adv Chemistry A Me(3)SI-mediated simple and efficient protocol for the chemoselective deprotection of acetyl groups has been developed via employing KMnO(4) as an additive. This chemoselective deacetylation is amenable to a wide range of substrates, tolerating diverse and sensitive functional groups in carbohydrates, amino acids, natural products, heterocycles, and general scaffolds. The protocol is attractive because it uses an environmentally benign reagent system to perform quantitative and clean transformations under ambient conditions. The Royal Society of Chemistry 2021-05-27 /pmc/articles/PMC9033574/ /pubmed/35478635 http://dx.doi.org/10.1039/d1ra03209g Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Gurawa, Aakanksha
Kumar, Manoj
Kashyap, Sudhir
Me(3)SI-promoted chemoselective deacetylation: a general and mild protocol
title Me(3)SI-promoted chemoselective deacetylation: a general and mild protocol
title_full Me(3)SI-promoted chemoselective deacetylation: a general and mild protocol
title_fullStr Me(3)SI-promoted chemoselective deacetylation: a general and mild protocol
title_full_unstemmed Me(3)SI-promoted chemoselective deacetylation: a general and mild protocol
title_short Me(3)SI-promoted chemoselective deacetylation: a general and mild protocol
title_sort me(3)si-promoted chemoselective deacetylation: a general and mild protocol
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9033574/
https://www.ncbi.nlm.nih.gov/pubmed/35478635
http://dx.doi.org/10.1039/d1ra03209g
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