Spatial collagen stiffening promotes collective breast cancer cell invasion by reinforcing extracellular matrix alignment

The tumor micro-environment often contains stiff and irregular-bundled collagen fibers that are used by tumor cells to disseminate. It is still unclear how and to what extent, extracellular matrix (ECM) stiffness versus ECM bundle size and alignment dictate cancer cell invasion. Here, we have uncoup...

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Detalles Bibliográficos
Autores principales: Koorman, Thijs, Jansen, Karin A., Khalil, Antoine, Haughton, Peter D., Visser, Daan, Rätze, Max A. K., Haakma, Wisse E., Sakalauskaitè, Gabrielè, van Diest, Paul J., de Rooij, Johan, Derksen, Patrick W. B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9033577/
https://www.ncbi.nlm.nih.gov/pubmed/35292774
http://dx.doi.org/10.1038/s41388-022-02258-1

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