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Determination of biogenic amines in alcoholic beverages using a novel fluorogenic compound as derivatizing reagent

Biogenic amines (BAs) are organic nitrogenous compounds that are responsible for several biological events. If their concentration reaches the threshold level, it can cause mild to serious health problems in human. A novel bis-styrylphenyl Meldrum's acid derivative (BSMAD) was synthesized and s...

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Autores principales: Zhu, Fangfang, Liu, Honglong, Zhang, Wenqing, Du, Chuanyuan, Zhu, Hao, Du, Xiaodi, Hu, Xiaosong, Lin, Yawei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9033611/
https://www.ncbi.nlm.nih.gov/pubmed/35479236
http://dx.doi.org/10.1039/d1ra01436f
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author Zhu, Fangfang
Liu, Honglong
Zhang, Wenqing
Du, Chuanyuan
Zhu, Hao
Du, Xiaodi
Hu, Xiaosong
Lin, Yawei
author_facet Zhu, Fangfang
Liu, Honglong
Zhang, Wenqing
Du, Chuanyuan
Zhu, Hao
Du, Xiaodi
Hu, Xiaosong
Lin, Yawei
author_sort Zhu, Fangfang
collection PubMed
description Biogenic amines (BAs) are organic nitrogenous compounds that are responsible for several biological events. If their concentration reaches the threshold level, it can cause mild to serious health problems in human. A novel bis-styrylphenyl Meldrum's acid derivative (BSMAD) was synthesized and served as a fluorescent turn-on pre-column derivatizing reagent for the quantitative analysis of BAs. A method for the determination of BA by high-performance liquid chromatography (HPLC) was established, which has a low detection limit (0.4 nmol L(−1)), excellent linearity (R(2) ≥ 0.9946) and repeatability (RSD ≤ 3.7% intra-day, RSD ≤ 5.8% inter-day). The proposed method was successfully applied for the determination of BAs in several alcoholic beverages, including yellow wine, red wine, cooking wine, and beer. Satisfactory recoveries were obtained in the range of 94.6–100.5%. Compared with other methods, this pre-column derivatization method using BSMAD is simple, reliable, highly sensitive, and of low interference, providing an effective method for future studies of BAs in different matrices.
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spelling pubmed-90336112022-04-26 Determination of biogenic amines in alcoholic beverages using a novel fluorogenic compound as derivatizing reagent Zhu, Fangfang Liu, Honglong Zhang, Wenqing Du, Chuanyuan Zhu, Hao Du, Xiaodi Hu, Xiaosong Lin, Yawei RSC Adv Chemistry Biogenic amines (BAs) are organic nitrogenous compounds that are responsible for several biological events. If their concentration reaches the threshold level, it can cause mild to serious health problems in human. A novel bis-styrylphenyl Meldrum's acid derivative (BSMAD) was synthesized and served as a fluorescent turn-on pre-column derivatizing reagent for the quantitative analysis of BAs. A method for the determination of BA by high-performance liquid chromatography (HPLC) was established, which has a low detection limit (0.4 nmol L(−1)), excellent linearity (R(2) ≥ 0.9946) and repeatability (RSD ≤ 3.7% intra-day, RSD ≤ 5.8% inter-day). The proposed method was successfully applied for the determination of BAs in several alcoholic beverages, including yellow wine, red wine, cooking wine, and beer. Satisfactory recoveries were obtained in the range of 94.6–100.5%. Compared with other methods, this pre-column derivatization method using BSMAD is simple, reliable, highly sensitive, and of low interference, providing an effective method for future studies of BAs in different matrices. The Royal Society of Chemistry 2021-06-01 /pmc/articles/PMC9033611/ /pubmed/35479236 http://dx.doi.org/10.1039/d1ra01436f Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Zhu, Fangfang
Liu, Honglong
Zhang, Wenqing
Du, Chuanyuan
Zhu, Hao
Du, Xiaodi
Hu, Xiaosong
Lin, Yawei
Determination of biogenic amines in alcoholic beverages using a novel fluorogenic compound as derivatizing reagent
title Determination of biogenic amines in alcoholic beverages using a novel fluorogenic compound as derivatizing reagent
title_full Determination of biogenic amines in alcoholic beverages using a novel fluorogenic compound as derivatizing reagent
title_fullStr Determination of biogenic amines in alcoholic beverages using a novel fluorogenic compound as derivatizing reagent
title_full_unstemmed Determination of biogenic amines in alcoholic beverages using a novel fluorogenic compound as derivatizing reagent
title_short Determination of biogenic amines in alcoholic beverages using a novel fluorogenic compound as derivatizing reagent
title_sort determination of biogenic amines in alcoholic beverages using a novel fluorogenic compound as derivatizing reagent
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9033611/
https://www.ncbi.nlm.nih.gov/pubmed/35479236
http://dx.doi.org/10.1039/d1ra01436f
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