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Cross-linking of a polyketide synthase domain leads to a recyclable biocatalyst for chiral oxygen heterocycle synthesis

The potential of polyketide synthase (PKS) domains for chemoenzymatic synthesis can often not be tapped due to their low stability and activity in vitro. In this proof-of-principle study, the immobilisation of the heterocycle-forming PKS domain AmbDH3 as a cross-linked enzyme aggregate (CLEA) is des...

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Detalles Bibliográficos
Autores principales: Wagner, Lisa, Roß, Theresa, Hollmann, Tim, Hahn, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9033652/
https://www.ncbi.nlm.nih.gov/pubmed/35479892
http://dx.doi.org/10.1039/d1ra03692k