The Hepatic Stellate Cells (HSTCs) and Adipose-derived Mesenchymal Stem Cells (ASCs) Axis as a Potential Major Driver of Metabolic Syndrome – Novel Concept and Therapeutic Implications

ABSTRACT: Herein, we would like to introduce a novel concept for the prevention and treatment of metabolic syndrome, which is based on molecular relationship between liver and adipose tissue. Particularly, we believe, that unravelling the molecular crosstalk between hepatokines and adipokines will a...

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Autores principales: Marycz, Krzysztof, Kornicka-Garbowska, Katarzyna, Galuppo, Larry, Bourebaba, Lynda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9033713/
https://www.ncbi.nlm.nih.gov/pubmed/34822062
http://dx.doi.org/10.1007/s12015-021-10304-w
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author Marycz, Krzysztof
Kornicka-Garbowska, Katarzyna
Galuppo, Larry
Bourebaba, Lynda
author_facet Marycz, Krzysztof
Kornicka-Garbowska, Katarzyna
Galuppo, Larry
Bourebaba, Lynda
author_sort Marycz, Krzysztof
collection PubMed
description ABSTRACT: Herein, we would like to introduce a novel concept for the prevention and treatment of metabolic syndrome, which is based on molecular relationship between liver and adipose tissue. Particularly, we believe, that unravelling the molecular crosstalk between hepatokines and adipokines will allow to better understand the pathophysiology of metabolic diseases and allow to develop novel, effective therapeutic solutions against obesity and metabolic syndrome. GRAPHICAL ABSTRACT: Inter-organ communication on the level of stem progenitor cells-hepatic stellate cells (HSTCs) and adipose-derived progenitors (ASCs) could represents a key mechanism involved in controlling glucose tolerance as well as insulin sensitivity. [Image: see text]
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spelling pubmed-90337132022-05-06 The Hepatic Stellate Cells (HSTCs) and Adipose-derived Mesenchymal Stem Cells (ASCs) Axis as a Potential Major Driver of Metabolic Syndrome – Novel Concept and Therapeutic Implications Marycz, Krzysztof Kornicka-Garbowska, Katarzyna Galuppo, Larry Bourebaba, Lynda Stem Cell Rev Rep Article ABSTRACT: Herein, we would like to introduce a novel concept for the prevention and treatment of metabolic syndrome, which is based on molecular relationship between liver and adipose tissue. Particularly, we believe, that unravelling the molecular crosstalk between hepatokines and adipokines will allow to better understand the pathophysiology of metabolic diseases and allow to develop novel, effective therapeutic solutions against obesity and metabolic syndrome. GRAPHICAL ABSTRACT: Inter-organ communication on the level of stem progenitor cells-hepatic stellate cells (HSTCs) and adipose-derived progenitors (ASCs) could represents a key mechanism involved in controlling glucose tolerance as well as insulin sensitivity. [Image: see text] Springer US 2021-11-25 2022 /pmc/articles/PMC9033713/ /pubmed/34822062 http://dx.doi.org/10.1007/s12015-021-10304-w Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Marycz, Krzysztof
Kornicka-Garbowska, Katarzyna
Galuppo, Larry
Bourebaba, Lynda
The Hepatic Stellate Cells (HSTCs) and Adipose-derived Mesenchymal Stem Cells (ASCs) Axis as a Potential Major Driver of Metabolic Syndrome – Novel Concept and Therapeutic Implications
title The Hepatic Stellate Cells (HSTCs) and Adipose-derived Mesenchymal Stem Cells (ASCs) Axis as a Potential Major Driver of Metabolic Syndrome – Novel Concept and Therapeutic Implications
title_full The Hepatic Stellate Cells (HSTCs) and Adipose-derived Mesenchymal Stem Cells (ASCs) Axis as a Potential Major Driver of Metabolic Syndrome – Novel Concept and Therapeutic Implications
title_fullStr The Hepatic Stellate Cells (HSTCs) and Adipose-derived Mesenchymal Stem Cells (ASCs) Axis as a Potential Major Driver of Metabolic Syndrome – Novel Concept and Therapeutic Implications
title_full_unstemmed The Hepatic Stellate Cells (HSTCs) and Adipose-derived Mesenchymal Stem Cells (ASCs) Axis as a Potential Major Driver of Metabolic Syndrome – Novel Concept and Therapeutic Implications
title_short The Hepatic Stellate Cells (HSTCs) and Adipose-derived Mesenchymal Stem Cells (ASCs) Axis as a Potential Major Driver of Metabolic Syndrome – Novel Concept and Therapeutic Implications
title_sort hepatic stellate cells (hstcs) and adipose-derived mesenchymal stem cells (ascs) axis as a potential major driver of metabolic syndrome – novel concept and therapeutic implications
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9033713/
https://www.ncbi.nlm.nih.gov/pubmed/34822062
http://dx.doi.org/10.1007/s12015-021-10304-w
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