Epigenetic upregulation of TET2 is an independent poor prognostic factor for intrahepatic cholangiocarcinoma

Mutations in IDH1/2 and the epigenetic silencing of TET2 occur in leukaemia or glioma in a mutually exclusive manner. Although intrahepatic cholangiocarcinoma (iCCA) may harbour IDH1/2 mutations, the contribution of TET2 to carcinogenesis remains unknown. In the present study, the expression and pro...

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Detalles Bibliográficos
Autores principales: Yamashita, Hironori, Tourna, Aikaterini, Akita, Masayuki, Itoh, Tomoo, Chokshi, Shilpa, Ajiki, Tetsuo, Fukumoto, Takumi, Youngson, Neil A., Zen, Yoh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9033729/
https://www.ncbi.nlm.nih.gov/pubmed/34905094
http://dx.doi.org/10.1007/s00428-021-03251-x

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