The Mechanism of Stem Cell Aging

Stem cells have self-renewal ability and multi-directional differentiation potential. They have tissue repair capabilities and are essential for maintaining the tissue homeostasis. The depletion of stem cells is closely related to the occurrence of body aging and aging-related diseases. Therefore, r...

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Autores principales: Mi, Liangyu, Hu, Junping, Li, Na, Gao, Jinfang, Huo, Rongxiu, Peng, Xinyue, Zhang, Na, Liu, Ying, Zhao, Hanxi, Liu, Ruiling, Zhang, Liyun, Xu, Ke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9033730/
https://www.ncbi.nlm.nih.gov/pubmed/35000109
http://dx.doi.org/10.1007/s12015-021-10317-5
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author Mi, Liangyu
Hu, Junping
Li, Na
Gao, Jinfang
Huo, Rongxiu
Peng, Xinyue
Zhang, Na
Liu, Ying
Zhao, Hanxi
Liu, Ruiling
Zhang, Liyun
Xu, Ke
author_facet Mi, Liangyu
Hu, Junping
Li, Na
Gao, Jinfang
Huo, Rongxiu
Peng, Xinyue
Zhang, Na
Liu, Ying
Zhao, Hanxi
Liu, Ruiling
Zhang, Liyun
Xu, Ke
author_sort Mi, Liangyu
collection PubMed
description Stem cells have self-renewal ability and multi-directional differentiation potential. They have tissue repair capabilities and are essential for maintaining the tissue homeostasis. The depletion of stem cells is closely related to the occurrence of body aging and aging-related diseases. Therefore, revealing the molecular mechanisms of stem cell aging will set new directions for the therapeutic application of stem cells, the study of aging mechanisms, and the prevention and treatment of aging-related diseases. This review comprehensively describes the molecular mechanisms related to stem cell aging and provides the basis for further investigations aimed at developing new anti-stem cell aging strategies and promoting the clinical application of stem cells.
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spelling pubmed-90337302022-05-06 The Mechanism of Stem Cell Aging Mi, Liangyu Hu, Junping Li, Na Gao, Jinfang Huo, Rongxiu Peng, Xinyue Zhang, Na Liu, Ying Zhao, Hanxi Liu, Ruiling Zhang, Liyun Xu, Ke Stem Cell Rev Rep Article Stem cells have self-renewal ability and multi-directional differentiation potential. They have tissue repair capabilities and are essential for maintaining the tissue homeostasis. The depletion of stem cells is closely related to the occurrence of body aging and aging-related diseases. Therefore, revealing the molecular mechanisms of stem cell aging will set new directions for the therapeutic application of stem cells, the study of aging mechanisms, and the prevention and treatment of aging-related diseases. This review comprehensively describes the molecular mechanisms related to stem cell aging and provides the basis for further investigations aimed at developing new anti-stem cell aging strategies and promoting the clinical application of stem cells. Springer US 2022-01-09 2022 /pmc/articles/PMC9033730/ /pubmed/35000109 http://dx.doi.org/10.1007/s12015-021-10317-5 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Mi, Liangyu
Hu, Junping
Li, Na
Gao, Jinfang
Huo, Rongxiu
Peng, Xinyue
Zhang, Na
Liu, Ying
Zhao, Hanxi
Liu, Ruiling
Zhang, Liyun
Xu, Ke
The Mechanism of Stem Cell Aging
title The Mechanism of Stem Cell Aging
title_full The Mechanism of Stem Cell Aging
title_fullStr The Mechanism of Stem Cell Aging
title_full_unstemmed The Mechanism of Stem Cell Aging
title_short The Mechanism of Stem Cell Aging
title_sort mechanism of stem cell aging
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9033730/
https://www.ncbi.nlm.nih.gov/pubmed/35000109
http://dx.doi.org/10.1007/s12015-021-10317-5
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