A targetable CoQ-FSP1 axis drives ferroptosis- and radiation-resistance in KEAP1 inactive lung cancers

Targeting ferroptosis, a unique cell death modality triggered by unrestricted lipid peroxidation, in cancer therapy is hindered by our incomplete understanding of ferroptosis mechanisms under specific cancer genetic contexts. KEAP1 (kelch-like ECH associated protein 1) is frequently mutated or inact...

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Detalles Bibliográficos
Autores principales: Koppula, Pranavi, Lei, Guang, Zhang, Yilei, Yan, Yuelong, Mao, Chao, Kondiparthi, Lavanya, Shi, Jiejun, Liu, Xiaoguang, Horbath, Amber, Das, Molina, Li, Wei, Poyurovsky, Masha V., Olszewski, Kellen, Gan, Boyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9033817/
https://www.ncbi.nlm.nih.gov/pubmed/35459868
http://dx.doi.org/10.1038/s41467-022-29905-1

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