Fusion protein-driven IGF-IR/PI3K/AKT signals deregulate Hippo pathway promoting oncogenic cooperation of YAP1 and FUS-DDIT3 in myxoid liposarcoma

Myxoid liposarcoma (MLS) represents a common subtype of liposarcoma molecularly characterized by a recurrent chromosomal translocation that generates a chimeric FUS-DDIT3 fusion gene. The FUS-DDIT3 oncoprotein has been shown to be crucial in MLS pathogenesis. Acting as a transcriptional dysregulator...

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Detalles Bibliográficos
Autores principales: Berthold, Ruth, Isfort, Ilka, Erkut, Cihan, Heinst, Lorena, Grünewald, Inga, Wardelmann, Eva, Kindler, Thomas, Åman, Pierre, Grünewald, Thomas G. P., Cidre-Aranaz, Florencia, Trautmann, Marcel, Fröhling, Stefan, Scholl, Claudia, Hartmann, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9033823/
https://www.ncbi.nlm.nih.gov/pubmed/35459264
http://dx.doi.org/10.1038/s41389-022-00394-7

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