Cargando…

Genetic analysis of over half a million people characterises C-reactive protein loci

Chronic low-grade inflammation is linked to a multitude of chronic diseases. We report the largest genome-wide association study (GWAS) on C-reactive protein (CRP), a marker of systemic inflammation, in UK Biobank participants (N = 427,367, European descent) and the Cohorts for Heart and Aging Resea...

Descripción completa

Detalles Bibliográficos
Autores principales:	Said, Saredo, Pazoki, Raha, Karhunen, Ville, Võsa, Urmo, Ligthart, Symen, Bodinier, Barbara, Koskeridis, Fotios, Welsh, Paul, Alizadeh, Behrooz Z., Chasman, Daniel I., Sattar, Naveed, Chadeau-Hyam, Marc, Evangelou, Evangelos, Jarvelin, Marjo-Riitta, Elliott, Paul, Tzoulaki, Ioanna, Dehghan, Abbas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9033829/ https://www.ncbi.nlm.nih.gov/pubmed/35459240 http://dx.doi.org/10.1038/s41467-022-29650-5

Ejemplares similares

Author Correction: Genetic analysis of over half a million people characterises C-reactive protein loci
por: Said, Saredo, et al.
Publicado: (2022)

Pleiotropic genetic architecture and novel loci for C-reactive protein levels
por: Koskeridis, Fotios, et al.
Publicado: (2022)

Determinants of accelerated metabolomic and epigenetic aging in a UK cohort
por: Robinson, Oliver, et al.
Publicado: (2020)

Predictive symptoms for COVID-19 in the community: REACT-1 study of over 1 million people
por: Elliott, Joshua, et al.
Publicado: (2021)

COVID-19 mortality in the UK Biobank cohort: revisiting and evaluating risk factors
por: Elliott, Joshua, et al.
Publicado: (2021)

Genetic fine-mapping from summary data using a nonlocal prior improves the detection of multiple causal variants
por: Karhunen, Ville, et al.
Publicado: (2023)

Risk factors for positive and negative COVID-19 tests: a cautious and in-depth analysis of UK biobank data
por: Chadeau-Hyam, Marc, et al.
Publicado: (2020)

Pleiotropy among Common Genetic Loci Identified for Cardiometabolic Disorders and C-Reactive Protein
por: Ligthart, Symen, et al.
Publicado: (2015)

Genetic variation in cervical preinvasive and invasive disease: a genome-wide association study
por: Bowden, Sarah J, et al.
Publicado: (2021)

The link between attention deficit hyperactivity disorder (ADHD) symptoms and obesity-related traits: genetic and prenatal explanations
por: Karhunen, Ville, et al.
Publicado: (2021)

Automated calibration of consensus weighted distance-based clustering approaches using sharp
por: Bodinier, Barbara, et al.
Publicado: (2023)

Commentary: CRP and schizophrenia: cause, consequence or confounding?
por: Ligthart, Symen
Publicado: (2019)

Inflammatory Diseases, Inflammatory Biomarkers, and Alzheimer Disease: An Observational Analysis and Mendelian Randomization
por: Huang, Jian, et al.
Publicado: (2023)

GWAS for urinary sodium and potassium excretion highlights pathways shared with cardiovascular traits
por: Pazoki, Raha, et al.
Publicado: (2019)

Exploring the causal effect of maternal pregnancy adiposity on offspring adiposity: Mendelian randomisation using polygenic risk scores
por: Bond, Tom A., et al.
Publicado: (2022)

Variant-specific symptoms of COVID-19 in a study of 1,542,510 adults in England
por: Whitaker, Matthew, et al.
Publicado: (2022)

Bivariate genome-wide association study identifies novel pleiotropic loci for lipids and inflammation
por: Ligthart, Symen, et al.
Publicado: (2016)

Altered Gene Expression Associated with microRNA Binding Site Polymorphisms
por: Võsa, Urmo, et al.
Publicado: (2015)

Education, biological ageing, all-cause and cause-specific mortality and morbidity: UK biobank cohort study
por: Chadeau-Hyam, Marc, et al.
Publicado: (2020)

Genetic analysis in European ancestry individuals identifies 517 loci associated with liver enzymes
por: Pazoki, Raha, et al.
Publicado: (2021)

Apt interpretation of comprehensive lipoprotein data in large-scale epidemiology: disclosure of fundamental structural and metabolic relationships
por: Ala-Korpela, Mika, et al.
Publicado: (2021)

Long-range regulatory effects of Neandertal DNA in modern humans
por: Yermakovich, Danat, et al.
Publicado: (2022)

Early exposure to social disadvantages and later life body mass index beyond genetic predisposition in three generations of Finnish birth cohorts
por: Lowry, Estelle, et al.
Publicado: (2020)

An epigenome-wide association study of metabolic syndrome and its components
por: Nuotio, Marja-Liisa, et al.
Publicado: (2020)

Obesity and Life Expectancy with and without Diabetes in Adults Aged 55 Years and Older in the Netherlands: A Prospective Cohort Study
por: Dhana, Klodian, et al.
Publicado: (2016)

Associations of genetically predicted fatty acid levels across the phenome: A mendelian randomisation study
por: Zagkos, Loukas, et al.
Publicado: (2022)

Evidence for involvement of the alcohol consumption WDPCP gene in lipid metabolism, and liver cirrhosis
por: O’Farrell, Felix, et al.
Publicado: (2023)

Metabolomic signatures of low birthweight: Pathways to insulin resistance and oxidative stress
por: Metrustry, Sarah Jane, et al.
Publicado: (2018)

Common variation at 16p11.2 is associated with glycosuria in pregnancy: findings from a genome-wide association study in European women
por: Lee, Matthew A, et al.
Publicado: (2020)

Association between Birth Characteristics and Cardiovascular Autonomic Function at Mid-Life
por: Perkiömäki, Nelli, et al.
Publicado: (2016)

Understanding the complexity of glycaemic health: systematic bio-psychosocial modelling of fasting glucose in middle-age adults; a DynaHEALTH study
por: Lowry, Estelle, et al.
Publicado: (2018)

Thyroid function and risk of type 2 diabetes: a population-based prospective cohort study
por: Chaker, Layal, et al.
Publicado: (2016)

Novel inflammatory markers for incident pre-diabetes and type 2 diabetes: the Rotterdam Study
por: Brahimaj, Adela, et al.
Publicado: (2017)

Identification of disease-associated loci using machine learning for genotype and network data integration
por: Leal, Luis G, et al.
Publicado: (2019)

Phenome-wide association study on miRNA-related sequence variants: the UK Biobank
por: Mustafa, Rima, et al.
Publicado: (2023)

Tissue-specific mitochondrial heteroplasmy at position 16,093 within the same individual
por: Krjutškov, Kaarel, et al.
Publicado: (2013)

Systematic review of worldwide variations of the prevalence of wheezing symptoms in children
por: Patel, Swatee P, et al.
Publicado: (2008)

Vitamin D and the Promotion of Long-Term Metabolic Health from a Programming Perspective
por: Palaniswamy, Saranya, et al.
Publicado: (2016)

Gene co-expression analysis for functional classification and gene–disease predictions
por: van Dam, Sipko, et al.
Publicado: (2017)

There is always glucose in normal urine: unspecific excretion associated with serum glucose and glomerular filtration rate
por: Li, Tianqi, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_i8a19uk2c4sqh8jgi965q8dt2k