A facile method for Rh-catalyzed decarbonylative ortho-C–H alkylation of (hetero)arenes with alkyl carboxylic acids

A facile and effective method for Rh-catalyzed direct ortho-alkylation of C–H bonds in (hetero)arenes with commercially available carboxylic acids has been developed. This strategy was initiated by in situ conversion of carboxylic acids to anhydrides which, without isolation, underwent Rh-catalyzed...

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Autores principales: Tian, Yiqiang, Liu, Xiaojie, He, Bangyue, Ren, Yuxi, Su, Weiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9033830/
https://www.ncbi.nlm.nih.gov/pubmed/35479217
http://dx.doi.org/10.1039/d1ra03992j
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author Tian, Yiqiang
Liu, Xiaojie
He, Bangyue
Ren, Yuxi
Su, Weiping
author_facet Tian, Yiqiang
Liu, Xiaojie
He, Bangyue
Ren, Yuxi
Su, Weiping
author_sort Tian, Yiqiang
collection PubMed
description A facile and effective method for Rh-catalyzed direct ortho-alkylation of C–H bonds in (hetero)arenes with commercially available carboxylic acids has been developed. This strategy was initiated by in situ conversion of carboxylic acids to anhydrides which, without isolation, underwent Rh-catalyzed direct decarbonylative cross-coupling of aryl carboxamides containing 8-aminoquinoline. The reaction proceeds with high regioselectivity and exhibits a broad substrate scope as well as functional group tolerance.
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spelling pubmed-90338302022-04-26 A facile method for Rh-catalyzed decarbonylative ortho-C–H alkylation of (hetero)arenes with alkyl carboxylic acids Tian, Yiqiang Liu, Xiaojie He, Bangyue Ren, Yuxi Su, Weiping RSC Adv Chemistry A facile and effective method for Rh-catalyzed direct ortho-alkylation of C–H bonds in (hetero)arenes with commercially available carboxylic acids has been developed. This strategy was initiated by in situ conversion of carboxylic acids to anhydrides which, without isolation, underwent Rh-catalyzed direct decarbonylative cross-coupling of aryl carboxamides containing 8-aminoquinoline. The reaction proceeds with high regioselectivity and exhibits a broad substrate scope as well as functional group tolerance. The Royal Society of Chemistry 2021-06-02 /pmc/articles/PMC9033830/ /pubmed/35479217 http://dx.doi.org/10.1039/d1ra03992j Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Tian, Yiqiang
Liu, Xiaojie
He, Bangyue
Ren, Yuxi
Su, Weiping
A facile method for Rh-catalyzed decarbonylative ortho-C–H alkylation of (hetero)arenes with alkyl carboxylic acids
title A facile method for Rh-catalyzed decarbonylative ortho-C–H alkylation of (hetero)arenes with alkyl carboxylic acids
title_full A facile method for Rh-catalyzed decarbonylative ortho-C–H alkylation of (hetero)arenes with alkyl carboxylic acids
title_fullStr A facile method for Rh-catalyzed decarbonylative ortho-C–H alkylation of (hetero)arenes with alkyl carboxylic acids
title_full_unstemmed A facile method for Rh-catalyzed decarbonylative ortho-C–H alkylation of (hetero)arenes with alkyl carboxylic acids
title_short A facile method for Rh-catalyzed decarbonylative ortho-C–H alkylation of (hetero)arenes with alkyl carboxylic acids
title_sort facile method for rh-catalyzed decarbonylative ortho-c–h alkylation of (hetero)arenes with alkyl carboxylic acids
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9033830/
https://www.ncbi.nlm.nih.gov/pubmed/35479217
http://dx.doi.org/10.1039/d1ra03992j
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