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Mechanism of sensitivity modulation in the calcium-sensing receptor via electrostatic tuning

Transfer of information across membranes is fundamental to the function of all organisms and is primarily initiated by transmembrane receptors. For many receptors, how ligand sensitivity is fine-tuned and how disease associated mutations modulate receptor conformation to allosterically affect recept...

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Detalles Bibliográficos
Autores principales: Schamber, Michael R., Vafabakhsh, Reza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9033857/
https://www.ncbi.nlm.nih.gov/pubmed/35459864
http://dx.doi.org/10.1038/s41467-022-29897-y