Cargando…
Comparison of the performance of magnetic targeting drug carriers prepared using two synthesis methods
In this paper, two methods were used to prepare the magnetic targeting drug carrier Fe(3)O(4)–PVA@SH, the step-by-step method and the one-pot method. The loading and release properties of the compound were measured. The results show that the Fe(3)O(4)–PVA@SH prepared using both methods exhibited exc...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9033997/ https://www.ncbi.nlm.nih.gov/pubmed/35479366 http://dx.doi.org/10.1039/d1ra04256d |
_version_ | 1784693017119031296 |
---|---|
author | Shi, Zhen Wang, Yazhen Dong, Shaobo Lan, Tianyu |
author_facet | Shi, Zhen Wang, Yazhen Dong, Shaobo Lan, Tianyu |
author_sort | Shi, Zhen |
collection | PubMed |
description | In this paper, two methods were used to prepare the magnetic targeting drug carrier Fe(3)O(4)–PVA@SH, the step-by-step method and the one-pot method. The loading and release properties of the compound were measured. The results show that the Fe(3)O(4)–PVA@SH prepared using both methods exhibited excellent drug delivery properties in an environment that simulates human body fluid (pH 7.2) and a lysosomal in vitro simulation (pH 4.7). In applications such as drug delivery, magnetic targeted drug carriers prepared by both methods demonstrated superparamagnetism, high fat solubility, high hydroxyl content, and good water solubility. |
format | Online Article Text |
id | pubmed-9033997 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | The Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-90339972022-04-26 Comparison of the performance of magnetic targeting drug carriers prepared using two synthesis methods Shi, Zhen Wang, Yazhen Dong, Shaobo Lan, Tianyu RSC Adv Chemistry In this paper, two methods were used to prepare the magnetic targeting drug carrier Fe(3)O(4)–PVA@SH, the step-by-step method and the one-pot method. The loading and release properties of the compound were measured. The results show that the Fe(3)O(4)–PVA@SH prepared using both methods exhibited excellent drug delivery properties in an environment that simulates human body fluid (pH 7.2) and a lysosomal in vitro simulation (pH 4.7). In applications such as drug delivery, magnetic targeted drug carriers prepared by both methods demonstrated superparamagnetism, high fat solubility, high hydroxyl content, and good water solubility. The Royal Society of Chemistry 2021-06-09 /pmc/articles/PMC9033997/ /pubmed/35479366 http://dx.doi.org/10.1039/d1ra04256d Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/ |
spellingShingle | Chemistry Shi, Zhen Wang, Yazhen Dong, Shaobo Lan, Tianyu Comparison of the performance of magnetic targeting drug carriers prepared using two synthesis methods |
title | Comparison of the performance of magnetic targeting drug carriers prepared using two synthesis methods |
title_full | Comparison of the performance of magnetic targeting drug carriers prepared using two synthesis methods |
title_fullStr | Comparison of the performance of magnetic targeting drug carriers prepared using two synthesis methods |
title_full_unstemmed | Comparison of the performance of magnetic targeting drug carriers prepared using two synthesis methods |
title_short | Comparison of the performance of magnetic targeting drug carriers prepared using two synthesis methods |
title_sort | comparison of the performance of magnetic targeting drug carriers prepared using two synthesis methods |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9033997/ https://www.ncbi.nlm.nih.gov/pubmed/35479366 http://dx.doi.org/10.1039/d1ra04256d |
work_keys_str_mv | AT shizhen comparisonoftheperformanceofmagnetictargetingdrugcarrierspreparedusingtwosynthesismethods AT wangyazhen comparisonoftheperformanceofmagnetictargetingdrugcarrierspreparedusingtwosynthesismethods AT dongshaobo comparisonoftheperformanceofmagnetictargetingdrugcarrierspreparedusingtwosynthesismethods AT lantianyu comparisonoftheperformanceofmagnetictargetingdrugcarrierspreparedusingtwosynthesismethods |