Novel structural insights for a pair of monoclonal antibodies recognizing non-overlapping epitopes of the glucosyltransferase domain of Clostridium difficile toxin B

Clostridium difficile toxins are the primary causative agents for hospital-acquired diarrhea and pseudomembranous colitis. Numerous monoclonal antibodies (mAbs) targeting different domains of Clostridium difficile toxin have been reported. Here we report the crystal structures of two mAbs, B1 and B2...

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Detalles Bibliográficos
Autores principales: Liu, Jinyu, Kothe, Michael, Zhang, Jianxin, Oloo, Eliud, Stegalkina, Svetlana, Mundle, Sophia T., Li, Lu, Zhang, Jinrong, Cole, Leah E., Barone, Lucianna, Biemann, Hans-Peter, Kleanthous, Harry, Anosova, Natalie G., Anderson, Stephen F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9034018/
https://www.ncbi.nlm.nih.gov/pubmed/35469152
http://dx.doi.org/10.1016/j.crstbi.2022.03.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9034018/
https://www.ncbi.nlm.nih.gov/pubmed/35469152
http://dx.doi.org/10.1016/j.crstbi.2022.03.003

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