Enzymatic analysis of WWP2 E3 ubiquitin ligase using protein microarrays identifies autophagy-related substrates

WWP2 is a HECT E3 ligase that targets protein Lys residues for ubiquitination and is comprised of an N-terminal C2 domain, four central WW domains, and a C-terminal catalytic HECT domain. The peptide segment between the middle WW domains, the 2,3-linker, is known to autoinhibit the catalytic domain,...

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Detalles Bibliográficos
Autores principales: Jiang, Hanjie, Chiang, Claire Y., Chen, Zan, Nathan, Sara, D’Agostino, Gabriel, Paulo, Joao A., Song, Guang, Zhu, Heng, Gabelli, Sandra B., Cole, Philip A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9034101/
https://www.ncbi.nlm.nih.gov/pubmed/35331737
http://dx.doi.org/10.1016/j.jbc.2022.101854

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