Microwave-assisted green construction of imidazole-fused hybrid scaffolds using 2-aminobenzimidazoles as building blocks

A class of trinuclear imidazole-fused hybrid scaffolds was constructed by the reaction of 2-(2-bromoaryl)- and 2-(2-bromovinyl)imidazoles with 2-aminobenzimidazoles as building blocks in the presence of a base under microwave irradiation. A nucleophilic aromatic substitution followed by cyclization...

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Detalles Bibliográficos
Autores principales: Kwak, Jung Pyo, Quang Dao, Pham Duy, Yoon, Nam Sik, Cho, Chan Sik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9034102/
https://www.ncbi.nlm.nih.gov/pubmed/35478827
http://dx.doi.org/10.1039/d1ra04396j
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author Kwak, Jung Pyo
Quang Dao, Pham Duy
Yoon, Nam Sik
Cho, Chan Sik
author_facet Kwak, Jung Pyo
Quang Dao, Pham Duy
Yoon, Nam Sik
Cho, Chan Sik
author_sort Kwak, Jung Pyo
collection PubMed
description A class of trinuclear imidazole-fused hybrid scaffolds was constructed by the reaction of 2-(2-bromoaryl)- and 2-(2-bromovinyl)imidazoles with 2-aminobenzimidazoles as building blocks in the presence of a base under microwave irradiation. A nucleophilic aromatic substitution followed by cyclization is proposed as a reaction pathway of this green process.
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spelling pubmed-90341022022-04-26 Microwave-assisted green construction of imidazole-fused hybrid scaffolds using 2-aminobenzimidazoles as building blocks Kwak, Jung Pyo Quang Dao, Pham Duy Yoon, Nam Sik Cho, Chan Sik RSC Adv Chemistry A class of trinuclear imidazole-fused hybrid scaffolds was constructed by the reaction of 2-(2-bromoaryl)- and 2-(2-bromovinyl)imidazoles with 2-aminobenzimidazoles as building blocks in the presence of a base under microwave irradiation. A nucleophilic aromatic substitution followed by cyclization is proposed as a reaction pathway of this green process. The Royal Society of Chemistry 2021-06-17 /pmc/articles/PMC9034102/ /pubmed/35478827 http://dx.doi.org/10.1039/d1ra04396j Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Kwak, Jung Pyo
Quang Dao, Pham Duy
Yoon, Nam Sik
Cho, Chan Sik
Microwave-assisted green construction of imidazole-fused hybrid scaffolds using 2-aminobenzimidazoles as building blocks
title Microwave-assisted green construction of imidazole-fused hybrid scaffolds using 2-aminobenzimidazoles as building blocks
title_full Microwave-assisted green construction of imidazole-fused hybrid scaffolds using 2-aminobenzimidazoles as building blocks
title_fullStr Microwave-assisted green construction of imidazole-fused hybrid scaffolds using 2-aminobenzimidazoles as building blocks
title_full_unstemmed Microwave-assisted green construction of imidazole-fused hybrid scaffolds using 2-aminobenzimidazoles as building blocks
title_short Microwave-assisted green construction of imidazole-fused hybrid scaffolds using 2-aminobenzimidazoles as building blocks
title_sort microwave-assisted green construction of imidazole-fused hybrid scaffolds using 2-aminobenzimidazoles as building blocks
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9034102/
https://www.ncbi.nlm.nih.gov/pubmed/35478827
http://dx.doi.org/10.1039/d1ra04396j
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AT yoonnamsik microwaveassistedgreenconstructionofimidazolefusedhybridscaffoldsusing2aminobenzimidazolesasbuildingblocks
AT chochansik microwaveassistedgreenconstructionofimidazolefusedhybridscaffoldsusing2aminobenzimidazolesasbuildingblocks

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