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Predictive modeling of resistance to SMO inhibition in a patient-derived orthotopic xenograft model of SHH medulloblastoma

BACKGROUND: Inhibition of the sonic hedgehog (SHH) pathway with Smoothened (SMO) inhibitors is a promising treatment strategy in SHH-activated medulloblastoma, especially in adult patients. However, the problem is that tumors frequently acquire resistance to the treatment. To understand the underlyi...

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Detalles Bibliográficos
Autores principales:	Krausert, Sonja, Brabetz, Sebastian, Mack, Norman L, Schmitt-Hoffner, Felix, Schwalm, Benjamin, Peterziel, Heike, Mangang, Aileen, Holland-Letz, Tim, Sieber, Laura, Korshunov, Andrey, Oehme, Ina, Jäger, Natalie, Witt, Olaf, Pfister, Stefan M, Kool, Marcel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Basic and Translational Investigations
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9034118/ https://www.ncbi.nlm.nih.gov/pubmed/35475274 http://dx.doi.org/10.1093/noajnl/vdac026

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