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Simple practical method for synthesis of trisubstituted imidazoles: an efficient copper catalyzed multicomponent reaction

A rapid practical process has been developed for synthesis of 2,4,5-trisubstituted-imidazoles in excellent yields up to 95% from readily available starting materials. In this CuI catalyzed synthesis, trisubstituted imidazoles were afforded in short reaction times, wherein the substrate scope is well...

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Autores principales: Kadu, Vikas D., Mali, Ganesh A., Khadul, Siddheshwar P., Kothe, Gokul J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9034145/
https://www.ncbi.nlm.nih.gov/pubmed/35480836
http://dx.doi.org/10.1039/d1ra01767e
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author Kadu, Vikas D.
Mali, Ganesh A.
Khadul, Siddheshwar P.
Kothe, Gokul J.
author_facet Kadu, Vikas D.
Mali, Ganesh A.
Khadul, Siddheshwar P.
Kothe, Gokul J.
author_sort Kadu, Vikas D.
collection PubMed
description A rapid practical process has been developed for synthesis of 2,4,5-trisubstituted-imidazoles in excellent yields up to 95% from readily available starting materials. In this CuI catalyzed synthesis, trisubstituted imidazoles were afforded in short reaction times, wherein the substrate scope is well explored with benzoin as well as benzil reacting with different aldehydes in the presence of ammonium acetate as the nitrogen source.
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spelling pubmed-90341452022-04-26 Simple practical method for synthesis of trisubstituted imidazoles: an efficient copper catalyzed multicomponent reaction Kadu, Vikas D. Mali, Ganesh A. Khadul, Siddheshwar P. Kothe, Gokul J. RSC Adv Chemistry A rapid practical process has been developed for synthesis of 2,4,5-trisubstituted-imidazoles in excellent yields up to 95% from readily available starting materials. In this CuI catalyzed synthesis, trisubstituted imidazoles were afforded in short reaction times, wherein the substrate scope is well explored with benzoin as well as benzil reacting with different aldehydes in the presence of ammonium acetate as the nitrogen source. The Royal Society of Chemistry 2021-06-22 /pmc/articles/PMC9034145/ /pubmed/35480836 http://dx.doi.org/10.1039/d1ra01767e Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Kadu, Vikas D.
Mali, Ganesh A.
Khadul, Siddheshwar P.
Kothe, Gokul J.
Simple practical method for synthesis of trisubstituted imidazoles: an efficient copper catalyzed multicomponent reaction
title Simple practical method for synthesis of trisubstituted imidazoles: an efficient copper catalyzed multicomponent reaction
title_full Simple practical method for synthesis of trisubstituted imidazoles: an efficient copper catalyzed multicomponent reaction
title_fullStr Simple practical method for synthesis of trisubstituted imidazoles: an efficient copper catalyzed multicomponent reaction
title_full_unstemmed Simple practical method for synthesis of trisubstituted imidazoles: an efficient copper catalyzed multicomponent reaction
title_short Simple practical method for synthesis of trisubstituted imidazoles: an efficient copper catalyzed multicomponent reaction
title_sort simple practical method for synthesis of trisubstituted imidazoles: an efficient copper catalyzed multicomponent reaction
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9034145/
https://www.ncbi.nlm.nih.gov/pubmed/35480836
http://dx.doi.org/10.1039/d1ra01767e
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