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Simple practical method for synthesis of trisubstituted imidazoles: an efficient copper catalyzed multicomponent reaction
A rapid practical process has been developed for synthesis of 2,4,5-trisubstituted-imidazoles in excellent yields up to 95% from readily available starting materials. In this CuI catalyzed synthesis, trisubstituted imidazoles were afforded in short reaction times, wherein the substrate scope is well...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9034145/ https://www.ncbi.nlm.nih.gov/pubmed/35480836 http://dx.doi.org/10.1039/d1ra01767e |
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author | Kadu, Vikas D. Mali, Ganesh A. Khadul, Siddheshwar P. Kothe, Gokul J. |
author_facet | Kadu, Vikas D. Mali, Ganesh A. Khadul, Siddheshwar P. Kothe, Gokul J. |
author_sort | Kadu, Vikas D. |
collection | PubMed |
description | A rapid practical process has been developed for synthesis of 2,4,5-trisubstituted-imidazoles in excellent yields up to 95% from readily available starting materials. In this CuI catalyzed synthesis, trisubstituted imidazoles were afforded in short reaction times, wherein the substrate scope is well explored with benzoin as well as benzil reacting with different aldehydes in the presence of ammonium acetate as the nitrogen source. |
format | Online Article Text |
id | pubmed-9034145 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | The Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-90341452022-04-26 Simple practical method for synthesis of trisubstituted imidazoles: an efficient copper catalyzed multicomponent reaction Kadu, Vikas D. Mali, Ganesh A. Khadul, Siddheshwar P. Kothe, Gokul J. RSC Adv Chemistry A rapid practical process has been developed for synthesis of 2,4,5-trisubstituted-imidazoles in excellent yields up to 95% from readily available starting materials. In this CuI catalyzed synthesis, trisubstituted imidazoles were afforded in short reaction times, wherein the substrate scope is well explored with benzoin as well as benzil reacting with different aldehydes in the presence of ammonium acetate as the nitrogen source. The Royal Society of Chemistry 2021-06-22 /pmc/articles/PMC9034145/ /pubmed/35480836 http://dx.doi.org/10.1039/d1ra01767e Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/ |
spellingShingle | Chemistry Kadu, Vikas D. Mali, Ganesh A. Khadul, Siddheshwar P. Kothe, Gokul J. Simple practical method for synthesis of trisubstituted imidazoles: an efficient copper catalyzed multicomponent reaction |
title | Simple practical method for synthesis of trisubstituted imidazoles: an efficient copper catalyzed multicomponent reaction |
title_full | Simple practical method for synthesis of trisubstituted imidazoles: an efficient copper catalyzed multicomponent reaction |
title_fullStr | Simple practical method for synthesis of trisubstituted imidazoles: an efficient copper catalyzed multicomponent reaction |
title_full_unstemmed | Simple practical method for synthesis of trisubstituted imidazoles: an efficient copper catalyzed multicomponent reaction |
title_short | Simple practical method for synthesis of trisubstituted imidazoles: an efficient copper catalyzed multicomponent reaction |
title_sort | simple practical method for synthesis of trisubstituted imidazoles: an efficient copper catalyzed multicomponent reaction |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9034145/ https://www.ncbi.nlm.nih.gov/pubmed/35480836 http://dx.doi.org/10.1039/d1ra01767e |
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