Design and synthesis of purine nucleoside analogues for the formation of stable anti-parallel-type triplex DNA with duplex DNA bearing the (5m)CG base pair

We herein demonstrated for the first time the direct recognition of duplex DNA bearing the 5-methyl-2′-deoxycytosine and 2′-deoxyguanosine base pair by triplex DNA formation. Triplex-forming oligonucleotides contained the novel artificial nucleoside analogues 2-amino-2′-deoxy-nebularine derivatives,...

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Autores principales: Notomi, Ryotaro, Wang, Lei, Sasaki, Shigeki, Taniguchi, Yosuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9034152/
https://www.ncbi.nlm.nih.gov/pubmed/35478801
http://dx.doi.org/10.1039/d1ra02831f
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author Notomi, Ryotaro
Wang, Lei
Sasaki, Shigeki
Taniguchi, Yosuke
author_facet Notomi, Ryotaro
Wang, Lei
Sasaki, Shigeki
Taniguchi, Yosuke
author_sort Notomi, Ryotaro
collection PubMed
description We herein demonstrated for the first time the direct recognition of duplex DNA bearing the 5-methyl-2′-deoxycytosine and 2′-deoxyguanosine base pair by triplex DNA formation. Triplex-forming oligonucleotides contained the novel artificial nucleoside analogues 2-amino-2′-deoxy-nebularine derivatives, and their molecular design, synthesis, and functional evaluation are described.
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spelling pubmed-90341522022-04-26 Design and synthesis of purine nucleoside analogues for the formation of stable anti-parallel-type triplex DNA with duplex DNA bearing the (5m)CG base pair Notomi, Ryotaro Wang, Lei Sasaki, Shigeki Taniguchi, Yosuke RSC Adv Chemistry We herein demonstrated for the first time the direct recognition of duplex DNA bearing the 5-methyl-2′-deoxycytosine and 2′-deoxyguanosine base pair by triplex DNA formation. Triplex-forming oligonucleotides contained the novel artificial nucleoside analogues 2-amino-2′-deoxy-nebularine derivatives, and their molecular design, synthesis, and functional evaluation are described. The Royal Society of Chemistry 2021-06-16 /pmc/articles/PMC9034152/ /pubmed/35478801 http://dx.doi.org/10.1039/d1ra02831f Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Notomi, Ryotaro
Wang, Lei
Sasaki, Shigeki
Taniguchi, Yosuke
Design and synthesis of purine nucleoside analogues for the formation of stable anti-parallel-type triplex DNA with duplex DNA bearing the (5m)CG base pair
title Design and synthesis of purine nucleoside analogues for the formation of stable anti-parallel-type triplex DNA with duplex DNA bearing the (5m)CG base pair
title_full Design and synthesis of purine nucleoside analogues for the formation of stable anti-parallel-type triplex DNA with duplex DNA bearing the (5m)CG base pair
title_fullStr Design and synthesis of purine nucleoside analogues for the formation of stable anti-parallel-type triplex DNA with duplex DNA bearing the (5m)CG base pair
title_full_unstemmed Design and synthesis of purine nucleoside analogues for the formation of stable anti-parallel-type triplex DNA with duplex DNA bearing the (5m)CG base pair
title_short Design and synthesis of purine nucleoside analogues for the formation of stable anti-parallel-type triplex DNA with duplex DNA bearing the (5m)CG base pair
title_sort design and synthesis of purine nucleoside analogues for the formation of stable anti-parallel-type triplex dna with duplex dna bearing the (5m)cg base pair
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9034152/
https://www.ncbi.nlm.nih.gov/pubmed/35478801
http://dx.doi.org/10.1039/d1ra02831f
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