Cargando…

In silico study of natural compounds from sesame against COVID-19 by targeting M(pro), PL(pro) and RdRp

Natural products and traditional medicine products with known safety profiles are a promising source for the discovery of new drug leads. Natural products as sesame were reported to exhibit potential to protect from COVID-19 disease. In our study, the total methanolic extract of Sesamum indicum L. s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Allam, Ahmed E., Amen, Yhiya, Ashour, Ahmed, Assaf, Hamdy K., Hassan, Heba Ali, Abdel-Rahman, Islam M., Sayed, Ahmed M., Shimizu, Kuniyoshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2021
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9034212/ https://www.ncbi.nlm.nih.gov/pubmed/35480825 http://dx.doi.org/10.1039/d1ra03937g

Ejemplares similares

RdRp or RT, That is the Question
por: Peyambari, Mahtab, et al.
Publicado: (2021)

Possible neuroprotective effects of amide alkaloids from Bassia indica and Agathophora alopecuroides: in vitro and in silico investigations
por: Othman, Ahmed, et al.
Publicado: (2022)

In silico investigation to identify potential small molecule inhibitors of the RNA-dependent RNA polymerase (RdRp) nidovirus RdRp-associated nucleotidyltransferase domain
por: Pitsillou, Eleni, et al.
Publicado: (2021)

Virtual screening based on the structure of more than 10(5) compounds against four key proteins of SARS-CoV-2: M(Pro), S(RBD), RdRp, and PL(pro)
por: Nabati, Farzan, et al.
Publicado: (2022)

In silico evaluation of Vitis amurensis Rupr. Polyphenol compounds for their inhibition potency against COVID-19 main enzymes M(pro) and RdRp
por: Souid, Imen, et al.
Publicado: (2022)

Snapshots of a Non-Canonical RdRP in Action
por: Ferrero, Diego S., et al.
Publicado: (2021)

Aging correlates with lower threshold cycle values for RdRP/RdRP+S genes during molecular detection of SARS-CoV-2
por: Mikuła-Pietrasik, Justyna, et al.
Publicado: (2021)

Derivation, Functionalization of (S)-Goniothalamin from Goniothalamus wightii and Their Derivative Targets SARS-CoV-2 M(Pro), S(Pro), and RdRp: A Pharmacological Perspective
por: Palani, Vino, et al.
Publicado: (2022)

Flavonols as potential antiviral drugs targeting SARS-CoV-2 proteases (3CL(pro) and PL(pro)), spike protein, RNA-dependent RNA polymerase (RdRp) and angiotensin-converting enzyme II receptor (ACE2)
por: Mouffouk, Chaima, et al.
Publicado: (2021)

Inhibition of HEV Replication by FDA-Approved RdRp Inhibitors
por: Hooda, Preeti, et al.
Publicado: (2023)

Evaluation of potential anti-RNA-dependent RNA polymerase (RdRP) drugs against the newly emerged model of COVID-19 RdRP using computational methods
por: Poustforoosh, Alireza, et al.
Publicado: (2021)

SARS-CoV-2 RdRp Inhibitors Selected from a Cell-Based SARS-CoV-2 RdRp Activity Assay System
por: Min, Jung Sun, et al.
Publicado: (2021)

RdRp inhibitors and COVID-19: Is molnupiravir a good option?
por: Hashemian, Seyed Mohammad Reza, et al.
Publicado: (2022)

An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
por: Allam, Ahmed E., et al.
Publicado: (2020)

In Silico Screening and Molecular Dynamics Simulation Studies in the Identification of Natural Compound Inhibitors Targeting the Human Norovirus RdRp Protein to Fight Gastroenteritis
por: Obaid, Rami J., et al.
Publicado: (2023)

Antiviral Protection via RdRP-Mediated Stable Activation of Innate Immunity
por: Painter, Meghan M., et al.
Publicado: (2015)

RdRp mutations are associated with SARS-CoV-2 genome evolution
por: Eskier, Doğa, et al.
Publicado: (2020)

The potential of Paritaprevir and Emetine as inhibitors of SARS-CoV-2 RdRp
por: Gurung, Arun Bahadur, et al.
Publicado: (2021)

RdRp-based sensitive taxonomic classification of RNA viruses for metagenomic data
por: Tang, Xubo, et al.
Publicado: (2022)

In silico structural elucidation of the rabies RNA-dependent RNA polymerase (RdRp) toward the identification of potential rabies virus inhibitors
por: Kiriwan, Duangnapa, et al.
Publicado: (2021)

Analysis of the codon usage pattern of the RdRP gene of mycovirus infecting Aspergillus spp.
por: Je, Mikyung, et al.
Publicado: (2019)

Targeting the RdRp of Emerging RNA Viruses: The Structure-Based Drug Design Challenge
por: Picarazzi, Francesca, et al.
Publicado: (2020)

RNA-dependent RNA polymerase (RdRp) natural antiviral inhibitors: a review
por: Leite, Daniela Regina Buch, et al.
Publicado: (2022)

Covalent Inhibitors from Saudi Medicinal Plants Target RNA-Dependent RNA Polymerase (RdRp) of SARS-CoV-2
por: Bakheit, Ahmed H., et al.
Publicado: (2023)

In Silico Exploration of Phytoconstituents From Phyllanthus emblica and Aegle marmelos as Potential Therapeutics Against SARS-CoV-2 RdRp
por: Pandey, Khushboo, et al.
Publicado: (2021)

In silico characterization of aryl benzoyl hydrazide derivatives as potential inhibitors of RdRp enzyme of H5N1 influenza virus
por: Ghosh, Abhishek, et al.
Publicado: (2022)

Melanin Synthesis Inhibition Activity of Compounds Isolated from Bamboo Shoot Skin (Phyllostachys pubescens)
por: Ashour, Ahmed, et al.
Publicado: (2022)

Discovery of divided RdRp sequences and a hitherto unknown genomic complexity in fungal viruses
por: Chiba, Yuto, et al.
Publicado: (2020)

In situ structures of polymerase complex of mammalian reovirus illuminate RdRp activation and transcription regulation
por: Bao, Keyan, et al.
Publicado: (2022)

Identification of RNA Virus–Derived RdRp Sequences in Publicly Available Transcriptomic Data Sets
por: Olendraite, Ingrida, et al.
Publicado: (2023)

Naturally Occurring Chromone Glycosides: Sources, Bioactivities, and Spectroscopic Features
por: Amen, Yhiya, et al.
Publicado: (2021)

Anticancer and Biological Effects of Some Natural Compounds and Theoretical Investigation of them Against RdRP of SARS-COV-2: In Silico and In Vitro Studies
por: Zhang, Jing, et al.
Publicado: (2023)

Development and validation of RdRp Screen, a crystallization screen for viral RNA-dependent RNA polymerases
por: Riccio, Federica, et al.
Publicado: (2019)

Antibiotic fidaxomicin is an RdRp inhibitor as a potential new therapeutic agent against Zika virus
por: Yuan, Jie, et al.
Publicado: (2020)

Mechanistic insight on the remdesivir binding to RNA-Dependent RNA polymerase (RdRp) of SARS-cov-2
por: Arba, Muhammad, et al.
Publicado: (2021)

RNA-dependent RNA polymerase (RdRp) inhibitors: The current landscape and repurposing for the COVID-19 pandemic
por: Tian, Lei, et al.
Publicado: (2021)

Polyphenols as Potential Inhibitors of SARS-CoV-2 RNA Dependent RNA Polymerase (RdRp)
por: Wu, Yifei, et al.
Publicado: (2021)

Allosteric activation of SARS-CoV-2 RdRp by remdesivir triphosphate and other phosphorylated nucleotides
por: Wang, Bing, et al.
Publicado: (2021)

Designing an effective therapeutic siRNA to silence RdRp gene of SARS-CoV-2
por: Shawan, Mohammad Mahfuz Ali Khan, et al.
Publicado: (2021)

Erratum: Discovery of divided RdRp sequences and a hitherto unknown genomic complexity in fungal viruses
por: Chiba, Yuto, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_t98v74nd4so3k3prs6eos3n950