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Characterization and application of natural and recombinant butelase-1 to improve industrial enzymes by end-to-end circularization

Butelase-1, an asparaginyl endopeptidase or legumain, is the prototypical and fastest known Asn/Asp-specific peptide ligase. It is highly useful for engineering and macrocyclization of peptides and proteins. However, certain biochemical properties and applications of naturally occurring and recombin...

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Detalles Bibliográficos
Autores principales: Hemu, Xinya, Zhang, Xiaohong, Nguyen, Giang K. T., To, Janet, Serra, Aida, Loo, Shining, Sze, Siu Kwan, Liu, Chuan-Fa, Tam, James P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9034278/
https://www.ncbi.nlm.nih.gov/pubmed/35480425
http://dx.doi.org/10.1039/d1ra03763c