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Alpha-hydroxytropolones are noncompetitive inhibitors of human RNase H1 that bind to the active site and modulate substrate binding

The ribonucleases H (RNases H) of HIV and hepatitis B virus are type 1 RNases H that are promising drug targets because inhibiting their activity blocks viral replication. Eukaryotic ribonuclease H1 (RNase H1) is an essential protein and a probable off-target enzyme for viral RNase H inhibitors. α-h...

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Detalles Bibliográficos
Autores principales:	Ponzar, Nathan L., Tajwar, Razia, Pozzi, Nicola, Tavis, John E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9034292/ https://www.ncbi.nlm.nih.gov/pubmed/35247386 http://dx.doi.org/10.1016/j.jbc.2022.101790

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