Synthesis of 2-methoxybenzamide derivatives and evaluation of their hedgehog signaling pathway inhibition

Aberrant hedgehog (Hh) signaling is implicated in the development of a variety of cancers. Smoothened (Smo) protein is a bottleneck in the Hh signal transduction. The regulation of the Hh signaling pathway to target the Smo receptor is a practical approach for development of anticancer agents. We re...

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Detalles Bibliográficos
Autores principales: Sun, Chiyu, Zhang, Dajun, Luan, Tian, Wang, Youbing, Zhang, Wenhu, Lin, Lin, Jiang, Meihua, Hao, Ziqian, Wang, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9034380/
https://www.ncbi.nlm.nih.gov/pubmed/35480433
http://dx.doi.org/10.1039/d1ra00732g

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