Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans

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BACKGROUND: α-Klotho is a geroprotective protein that can attenuate or alleviate deleterious changes with ageing and disease. Declines in α-Klotho play a role in the pathophysiology of multiple diseases and age-related phenotypes. Pre-clinical evidence suggests that boosting α-Klotho holds therapeut...

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Detalles Bibliográficos
Autores principales: Zhu, Yi, Prata, Larissa G.P. Langhi, Gerdes, Erin O. Wissler, Netto, Jair Machado Espindola, Pirtskhalava, Tamar, Giorgadze, Nino, Tripathi, Utkarsh, Inman, Christina L., Johnson, Kurt O., Xue, Ailing, Palmer, Allyson K., Chen, Tingjun, Schaefer, Kalli, Justice, Jamie N., Nambiar, Anoop M., Musi, Nicolas, Kritchevsky, Stephen B., Chen, Jun, Khosla, Sundeep, Jurk, Diana, Schafer, Marissa J., Tchkonia, Tamar, Kirkland, James L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
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Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9034457/
https://www.ncbi.nlm.nih.gov/pubmed/35292270
http://dx.doi.org/10.1016/j.ebiom.2022.103912
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