Genome-wide CRISPR screen identified Rad18 as a determinant of doxorubicin sensitivity in osteosarcoma

BACKGROUND: Osteosarcoma (OS) is a malignant bone tumor mostly occurring in children and adolescents, while chemotherapy resistance often develops and the mechanisms involved remain challenging to be fully investigated. METHODS: Genome-wide CRISPR screening combined with transcriptomic sequencing we...

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Detalles Bibliográficos
Autores principales: Du, Mingrui, Gu, Jintao, Liu, Chenlin, Liu, Nannan, Yu, Zhe, Zhou, Chengpei, Heng, Wei, Cao, Zhengcong, Wei, Feilong, Zhu, Kailong, Wang, Yingwen, Zhang, Wei, Xue, Xiaochang, Zhang, Yong, Qian, Jixian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9034549/
https://www.ncbi.nlm.nih.gov/pubmed/35459258
http://dx.doi.org/10.1186/s13046-022-02344-y

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