A novel cocktail therapy based on quintuplet combination of oncolytic herpes simplex virus-2 vectors armed with interleukin-12, interleukin-15, GM-CSF, PD1v, and IL-7 × CCL19 results in enhanced antitumor efficacy

BACKGROUND: Selectively replicating herpes simplex virus-2 (HSV-2) vector is a promising treatment for cancer therapy. The insertion of multiple transgenes into the viral genome has been performed to improve its oncolytic activity. METHODS: Herein, we simultaneously constructed five “armed” oncolyti...

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Detalles Bibliográficos
Autores principales: Hu, Han, Zhang, Siqi, Cai, Linkang, Duan, Haixiao, Li, Yuying, Yang, Junhan, Wang, Yang, Liu, Biao, Dong, Shuang, Fang, Zhizheng, Liu, Binlei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9034647/
https://www.ncbi.nlm.nih.gov/pubmed/35459242
http://dx.doi.org/10.1186/s12985-022-01795-1

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