Comparative study of therapy‐related and de novo adult b‐cell acute lymphoblastic leukaemia

We report a comparative analysis of patients with therapy‐related acute lymphoblastic leukaemia (tr‐ALL) vs de novo ALL. We identified 331 patients with B‐ALL; 69 (21%) were classified as tr‐ALL. The most common prior malignancies were breast (23·2%) and plasma cell disorders (20·3%). Patients with...

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Detalles Bibliográficos
Autores principales: Abdel Rahman, Zaid H., Parrondo, Ricardo D., Heckman, Michael G., Wieczorek, Mikolaj, Miller, Kevin C., Alkhateeb, Hassan, Sproat, Lisa Z., Murthy, Hemant, Hogan, William J., Kharfan‐Dabaja, Mohamed A., Peterson, Jess F., Baughn, Linda B., Hoppman, Nicole, Litzow, Mark R., Ketterling, Rhett P., Greipp, Patricia T., Foran, James M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Haematological malignancy–Clinical
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9034764/
https://www.ncbi.nlm.nih.gov/pubmed/34697797
http://dx.doi.org/10.1111/bjh.17906
Descripción
Sumario:We report a comparative analysis of patients with therapy‐related acute lymphoblastic leukaemia (tr‐ALL) vs de novo ALL. We identified 331 patients with B‐ALL; 69 (21%) were classified as tr‐ALL. The most common prior malignancies were breast (23·2%) and plasma cell disorders (20·3%). Patients with tr‐ALL were older (median 63·2 vs. 46·2 years, P < 0.001), more often female (66·7% vs. 43·5%, P < 0·001), and more likely to have hypodiploid cytogenetics (18·8% vs. 5·0%, P < 0·001). In multivariable analysis, patients with tr‐ALL were less likely to achieve complete remission [odds ratio (OR) = 0·16, P < 0·001] and more likely to be minimal residual disease‐positive (OR = 4·86, P = 0·01) but had similar OS after diagnosis and allo‐haematopoietic cell transplantation.

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