Potential Protective Effects of Antioxidants against Cyclophosphamide-Induced Nephrotoxicity

Cyclophosphamide is an alkylating antineoplastic agent, and it is one of the most successful drugs with wide arrays of clinical activity. It has been in use for several types of cancer treatments and as an immunosuppressive agent for the management of autoimmune and immune-mediated diseases. Nowaday...

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Detalles Bibliográficos
Autores principales: Ayza, Muluken Altaye, Zewdie, Kaleab Alemayehu, Yigzaw, Elias Fitsum, Ayele, Solomon Gashaw, Tesfaye, Bekalu Amare, Tafere, Gebrehiwot Gebremedhin, Abrha, Muzey Gebreyohannes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9034963/
https://www.ncbi.nlm.nih.gov/pubmed/35469319
http://dx.doi.org/10.1155/2022/5096825
Descripción
Sumario:Cyclophosphamide is an alkylating antineoplastic agent, and it is one of the most successful drugs with wide arrays of clinical activity. It has been in use for several types of cancer treatments and as an immunosuppressive agent for the management of autoimmune and immune-mediated diseases. Nowadays, its clinical use is limited due to various toxicities, including nephrotoxicity. Even though the mechanisms are not well understood, cyclophosphamide-induced nephrotoxicity is reported to be mediated through oxidative stress. This review focuses on the potential role of natural and plant-derived antioxidants in preventing cyclophosphamide-induced nephrotoxicity.

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