Potential Protective Effects of Antioxidants against Cyclophosphamide-Induced Nephrotoxicity

Cyclophosphamide is an alkylating antineoplastic agent, and it is one of the most successful drugs with wide arrays of clinical activity. It has been in use for several types of cancer treatments and as an immunosuppressive agent for the management of autoimmune and immune-mediated diseases. Nowaday...

Descripción completa

Detalles Bibliográficos
Autores principales: Ayza, Muluken Altaye, Zewdie, Kaleab Alemayehu, Yigzaw, Elias Fitsum, Ayele, Solomon Gashaw, Tesfaye, Bekalu Amare, Tafere, Gebrehiwot Gebremedhin, Abrha, Muzey Gebreyohannes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9034963/
https://www.ncbi.nlm.nih.gov/pubmed/35469319
http://dx.doi.org/10.1155/2022/5096825
_version_ 1784693215885000704
author Ayza, Muluken Altaye
Zewdie, Kaleab Alemayehu
Yigzaw, Elias Fitsum
Ayele, Solomon Gashaw
Tesfaye, Bekalu Amare
Tafere, Gebrehiwot Gebremedhin
Abrha, Muzey Gebreyohannes
author_facet Ayza, Muluken Altaye
Zewdie, Kaleab Alemayehu
Yigzaw, Elias Fitsum
Ayele, Solomon Gashaw
Tesfaye, Bekalu Amare
Tafere, Gebrehiwot Gebremedhin
Abrha, Muzey Gebreyohannes
author_sort Ayza, Muluken Altaye
collection PubMed
description Cyclophosphamide is an alkylating antineoplastic agent, and it is one of the most successful drugs with wide arrays of clinical activity. It has been in use for several types of cancer treatments and as an immunosuppressive agent for the management of autoimmune and immune-mediated diseases. Nowadays, its clinical use is limited due to various toxicities, including nephrotoxicity. Even though the mechanisms are not well understood, cyclophosphamide-induced nephrotoxicity is reported to be mediated through oxidative stress. This review focuses on the potential role of natural and plant-derived antioxidants in preventing cyclophosphamide-induced nephrotoxicity.
format Online
Article
Text
id pubmed-9034963
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-90349632022-04-24 Potential Protective Effects of Antioxidants against Cyclophosphamide-Induced Nephrotoxicity Ayza, Muluken Altaye Zewdie, Kaleab Alemayehu Yigzaw, Elias Fitsum Ayele, Solomon Gashaw Tesfaye, Bekalu Amare Tafere, Gebrehiwot Gebremedhin Abrha, Muzey Gebreyohannes Int J Nephrol Review Article Cyclophosphamide is an alkylating antineoplastic agent, and it is one of the most successful drugs with wide arrays of clinical activity. It has been in use for several types of cancer treatments and as an immunosuppressive agent for the management of autoimmune and immune-mediated diseases. Nowadays, its clinical use is limited due to various toxicities, including nephrotoxicity. Even though the mechanisms are not well understood, cyclophosphamide-induced nephrotoxicity is reported to be mediated through oxidative stress. This review focuses on the potential role of natural and plant-derived antioxidants in preventing cyclophosphamide-induced nephrotoxicity. Hindawi 2022-04-16 /pmc/articles/PMC9034963/ /pubmed/35469319 http://dx.doi.org/10.1155/2022/5096825 Text en Copyright © 2022 Muluken Altaye Ayza et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Ayza, Muluken Altaye
Zewdie, Kaleab Alemayehu
Yigzaw, Elias Fitsum
Ayele, Solomon Gashaw
Tesfaye, Bekalu Amare
Tafere, Gebrehiwot Gebremedhin
Abrha, Muzey Gebreyohannes
Potential Protective Effects of Antioxidants against Cyclophosphamide-Induced Nephrotoxicity
title Potential Protective Effects of Antioxidants against Cyclophosphamide-Induced Nephrotoxicity
title_full Potential Protective Effects of Antioxidants against Cyclophosphamide-Induced Nephrotoxicity
title_fullStr Potential Protective Effects of Antioxidants against Cyclophosphamide-Induced Nephrotoxicity
title_full_unstemmed Potential Protective Effects of Antioxidants against Cyclophosphamide-Induced Nephrotoxicity
title_short Potential Protective Effects of Antioxidants against Cyclophosphamide-Induced Nephrotoxicity
title_sort potential protective effects of antioxidants against cyclophosphamide-induced nephrotoxicity
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9034963/
https://www.ncbi.nlm.nih.gov/pubmed/35469319
http://dx.doi.org/10.1155/2022/5096825
work_keys_str_mv AT ayzamulukenaltaye potentialprotectiveeffectsofantioxidantsagainstcyclophosphamideinducednephrotoxicity
AT zewdiekaleabalemayehu potentialprotectiveeffectsofantioxidantsagainstcyclophosphamideinducednephrotoxicity
AT yigzaweliasfitsum potentialprotectiveeffectsofantioxidantsagainstcyclophosphamideinducednephrotoxicity
AT ayelesolomongashaw potentialprotectiveeffectsofantioxidantsagainstcyclophosphamideinducednephrotoxicity
AT tesfayebekaluamare potentialprotectiveeffectsofantioxidantsagainstcyclophosphamideinducednephrotoxicity
AT taferegebrehiwotgebremedhin potentialprotectiveeffectsofantioxidantsagainstcyclophosphamideinducednephrotoxicity
AT abrhamuzeygebreyohannes potentialprotectiveeffectsofantioxidantsagainstcyclophosphamideinducednephrotoxicity

Ejemplares similares