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Multiplexed genome regulation in vivo with hyper-efficient Cas12a

Multiplexed modulation of endogenous genes is crucial for sophisticated gene therapy and cell engineering. CRISPR-Cas12a systems enable versatile multiple genomic loci targeting by processing numerous crRNAs from a single transcript, however, their low efficiency has hindered applications in vivo. T...

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Detalles Bibliográficos
Autores principales:	Guo, Lucie Y., Bian, Jing, Davis, Alexander E., Liu, Pingting, Kempton, Hannah R., Zhang, Xiaowei, Chemparathy, Augustine, Gu, Baokun, Lin, Xueqiu, Rane, Draven A., Jamiolkowski, Ryan M., Hu, Yang, Wang, Sui, Qi, Lei S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9035114/ https://www.ncbi.nlm.nih.gov/pubmed/35414015 http://dx.doi.org/10.1038/s41556-022-00870-7

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