Cargando…

PINK1 ameliorates acute-on-chronic liver failure by inhibiting apoptosis through mTORC2/AKT signaling

Acute-on-chronic liver failure (ACLF) is a lethal syndrome with a remarkable short-term death rate. Even worse, effective internal medicine therapies are currently lacking. Increasing evidence indicates apoptosis plays a critical role in the progression of liver failure. PINK1 has an essential funct...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yin, Xuehong, Xue, Ran, Wu, Jing, Wu, Muchen, Xie, Bangxiang, Meng, Qinghua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9035184/ https://www.ncbi.nlm.nih.gov/pubmed/35461334 http://dx.doi.org/10.1038/s41420-022-01021-5

Ejemplares similares

Nrf2-Mediated Ferroptosis Inhibition Exerts a Protective Effect on Acute-on-Chronic Liver Failure
por: Wu, Jing, et al.
Publicado: (2022)

Ferroptosis in liver disease: new insights into disease mechanisms
por: Wu, Jing, et al.
Publicado: (2021)

Transient Inhibition of mTORC1 Signaling Ameliorates Irradiation-Induced Liver Damage
por: Yang, Wuping, et al.
Publicado: (2019)

SNS-032 inhibits mTORC1/mTORC2 activity in acute myeloid leukemia cells and has synergistic activity with perifosine against Akt
por: Meng, Haitao, et al.
Publicado: (2013)

Pathogenic Role of mTORC1 and mTORC2 in Pulmonary Hypertension
por: Tang, Haiyang, et al.
Publicado: (2018)

mTORC1 and mTORC2 in cancer and the tumor microenvironment
por: Kim, Laura C., et al.
Publicado: (2016)

c-FLIP links mTORC2 to apoptosis
por: Zhao, Liqun, et al.
Publicado: (2014)

Livers with Constitutive mTORC1 Activity Resist Steatosis Independent of Feedback Suppression of Akt
por: Kenerson, Heidi L., et al.
Publicado: (2015)

Insulin Stimulates Adipogenesis through the Akt-TSC2-mTORC1 Pathway
por: Zhang, Hui H., et al.
Publicado: (2009)

MFN2 suppresses cancer progression through inhibition of mTORC2/Akt signaling
por: Xu, Ke, et al.
Publicado: (2017)

Rapamycin Ameliorates Inflammation and Fibrosis in the Early Phase of Cirrhotic Portal Hypertension in Rats through Inhibition of mTORC1 but Not mTORC2
por: Wang, Weijie, et al.
Publicado: (2014)

High glutamine suppresses osteogenesis through mTORC1-mediated inhibition of the mTORC2/AKT-473/RUNX2 axis
por: Gayatri, Meher Bolisetti, et al.
Publicado: (2022)

Rapamycin inhibits mSin1 phosphorylation independently of mTORC1 and mTORC2
por: Luo, Yan, et al.
Publicado: (2015)

Phosphorylation of androgen receptor by mTORC1 promotes liver steatosis and tumorigenesis
por: Ren, Qian‐Nan, et al.
Publicado: (2021)

SREBP Activity Is Regulated by mTORC1 and Contributes to Akt-Dependent Cell Growth
por: Porstmann, Thomas, et al.
Publicado: (2008)

Translationally controlled tumor protein promotes liver regeneration by activating mTORC2/AKT signaling
por: Lin, Zhibin, et al.
Publicado: (2020)

Both mTORC1 and mTORC2 are involved in the regulation of cell adhesion
por: Chen, Long, et al.
Publicado: (2015)

The metabolic waste ammonium regulates mTORC2 and mTORC1 signaling
por: Merhi, Ahmad, et al.
Publicado: (2017)

mTORC1 is necessary but mTORC2 and GSK3β are inhibitory for AKT3-induced axon regeneration in the central nervous system
por: Miao, Linqing, et al.
Publicado: (2016)

RES-529: a PI3K/AKT/mTOR pathway inhibitor that dissociates the mTORC1 and mTORC2 complexes
por: Weinberg, Mark A.
Publicado: (2016)

F‐actin rearrangement is regulated by mTORC2/Akt/Girdin in mouse fertilized eggs
por: Wu, Didi, et al.
Publicado: (2016)

Hoxa5 increases mitochondrial apoptosis by inhibiting Akt/mTORC1/S6K1 pathway in mice white adipocytes
por: Feng, Fei, et al.
Publicado: (2017)

Cytoplasmic Endonuclease G promotes nonalcoholic fatty liver disease via mTORC2-AKT-ACLY and endoplasmic reticulum stress
por: Wang, Wenjun, et al.
Publicado: (2023)

GILZ inhibits the mTORC2/AKT pathway in BCR-ABL(+) cells
por: Joha, S, et al.
Publicado: (2012)

Dynamic Adipocyte Phosphoproteome Reveals that Akt Directly Regulates mTORC2
por: Humphrey, Sean J., et al.
Publicado: (2013)

Role of AKT/mTORC1 pathway in pancreatic β-cell proliferation.
por: Balcazar Morales, Norman, et al.
Publicado: (2012)

Roles of PINK1, mTORC2, and mitochondria in preserving brain tumor-forming stem cells in a noncanonical Notch signaling pathway
por: Lee, Kyu-Sun, et al.
Publicado: (2013)

mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation
por: Ding, Xiaolei, et al.
Publicado: (2016)

LPS Induces mTORC1 and mTORC2 Activation During Monocyte Adhesion
por: Ribeiro, Marcelle C., et al.
Publicado: (2018)

mTORC1 and mTORC2 differentially promote natural killer cell development
por: Yang, Chao, et al.
Publicado: (2018)

mTORC1 and mTORC2 are differentially engaged in the development of laser-induced CNV
por: Yang, Jin Young, et al.
Publicado: (2019)

Dopamine neuron morphology and output are differentially controlled by mTORC1 and mTORC2
por: Kosillo, Polina, et al.
Publicado: (2022)

Correction: Translationally controlled tumor protein promotes liver regeneration by activating mTORC2/AKT signaling
por: Lin, Zhibin, et al.
Publicado: (2020)

PINK1/BRPK inhibits apoptotic cell death and enahances cellular invasiveness through an activation of mTORC2 pathway
por: Murata, Hitoshi, et al.
Publicado: (2010)

Pyruvate Kinase M2 Activates mTORC1 by Phosphorylating AKT1S1
por: He, Chang-Liang, et al.
Publicado: (2016)

Regulation of Autophagy through TORC1 and mTORC1
por: Noda, Takeshi
Publicado: (2017)

Sophoricoside ameliorates cardiac hypertrophy by activating AMPK/mTORC1-mediated autophagy
por: Gao, Maomao, et al.
Publicado: (2020)

Akt and mTORC1 signaling as predictive biomarkers for the EGFR antibody nimotuzumab in glioblastoma
por: Ronellenfitsch, Michael W., et al.
Publicado: (2018)

mTORC2/Akt activation in adipocytes is required for adipose tissue inflammation in tuberculosis
por: Martinez, Nuria, et al.
Publicado: (2019)

TRIB3 suppresses tumorigenesis by controlling mTORC2/AKT/FOXO signaling
por: Salazar, María, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_atlcfc5kdusurh7c698245h76v